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BACKGROUND Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture-healing and spinal fusion. The optimal BMPs to be used in different clinical applications have not been elucidated, and a comprehensive evaluation of the relative osteogenic(More)
STUDY DESIGN Prospective multicenter nonrandomized institutional review board-approved observational study of clinical and radiographic outcomes of the extreme lateral interbody fusion (XLIF) procedure in adult scoliosis. OBJECTIVE Perioperative measures from this longitudinal study were compiled to identify the short-term results and complications of the(More)
STUDY DESIGN Prospective, multicenter, randomized Food and Drug Administration approved investigational device exemption clinical trial. OBJECTIVE To evaluate the safety and effectiveness of the PCM Cervical Disc compared with anterior cervical discectomy and fusion (ACDF) in the treatment of patients with degenerative spondylosis and neurological(More)
BACKGROUND CONTEXT Emerging literature suggests superior clinical short- and long-term outcomes of MIS (minimally invasive surgery) TLIFs (transforaminal lumbar interbody fusion) versus open fusions. Few studies to date have analyzed the cost differences between the two techniques and their relationship to acute clinical outcomes. PURPOSE The purpose of(More)
STUDY DESIGN A cadaveric study. OBJECTIVE To define the relationship of the lumbar exiting nerve root and trunks within the psoas muscle with reference to the radiographic center of the intervertebral disc, the recommended disc access point for the minimally invasive lateral transpsoas approach. SUMMARY OF BACKGROUND DATA The transpsoas approach to the(More)
STUDY DESIGN A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES To deliver a potentially therapeutic viral vector(More)
STUDY DESIGN A literature review of experiences with vertebroplasty and kyphoplasty for treating symptomatic, osteoporotic vertebral compression fractures (VCFs). OBJECTIVES To summarize the advantages and disadvantages of kyphoplasty and vertebroplasty. SUMMARY OF BACKGROUND DATA Osteoporotic VCFs are a leading cause of disability and morbidity in the(More)
STUDY DESIGN Human lumbar intervertebral discs from individuals of varying ages were obtained at autopsy and analyzed for collagen crosslinks. OBJECTIVES To analyze alterations in collagen crosslinks in human lumbar intervertebral discs with aging and disc degeneration. Crosslinks studied were pyridinoline, which is a collagen maturation crosslink, and(More)
STUDY DESIGN The current study of 251 consecutive 1-level anterior cervical reconstructions was undertaken to compare the incidence of dysphagia between cervical disk replacement and conventional anterior cervical fusion and instrumentation. OBJECTIVES This is a report of 251 patients from 5 investigational centers in the Food and drug Administration's(More)
BACKGROUND CONTEXT Although autogenous bone is still considered to be the gold standard graft material for promoting spinal fusion, other bone graft substitutes have been developed in an attempt to improve arthrodesis rates and avoid the complications associated with the procurement of autograft. The bone morphogenetic proteins (BMPs) represent a family of(More)