Frank McKeon

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

Annie Yang, Mourad Kaghad, +6 authors Frank McKeon
Molecular cell
1998

We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a variety of human and mouse… (More)

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

Mourad Kaghad, Helene Bonnet, +10 authors Daniel Caput
Cell
1997

We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought… (More)

The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase

Stephen S Taylor, Edward Ha, Frank McKeon
The Journal of cell biology
1998

A feedback control mechanism, or cell cycle checkpoint, delays the onset of anaphase until all the chromosomes are correctly aligned on the mitotic spindle. Previously, we showed that the murine… (More)

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit… (More)

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

Hong-gang Wang, Nuzhat I. Pathan, +7 authors John C. Reed
Science
1999

The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus… (More)

p63 identifies keratinocyte stem cells.

Graziella Pellegrini, Elena Dellambra, +6 authors Michele De Luca
Proceedings of the National Academy of Sciences…
2001

The proliferative compartment of stratified squamous epithelia consists of stem and transient amplifying (TA) keratinocytes. Some polypeptides are more abundant in putative epidermal stem cells than… (More)

p63 protects the female germ line during meiotic arrest

Eun-Kyung Suh, Annie Yang, +6 authors Frank McKeon
Nature
2006

Meiosis in the female germ line of mammals is distinguished by a prolonged arrest in prophase of meiosis I between homologous chromosome recombination and ovulation. How DNA damage is detected in… (More)

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.

Christine D Pozniak, Stevo Radinovic, Angela Yang, Frank McKeon, David R Kaplan, F. D. Miller
Science
2000

p53 plays an essential pro-apoptotic role, a function thought to be shared with its family members p73 and p63. Here, we show that p73 is primarily present in developing neurons as a truncated… (More)

Heterozygous Germline Mutations in the p53 Homolog p63 Are the Cause of EEC Syndrome

Jacopo Celli, Pascal H. G. Duijf, +16 authors Hans van Bokhoven
Cell
1999

EEC syndrome is an autosomal dominant disorder characterized by ectrodactyly, ectodermal dysplasia, and facial clefts. We have mapped the genetic defect in several EEC syndrome families to a region… (More)

p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

Makoto Senoo, Filipa R. Pinto, Frank McKeon
Cell
2007

The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to the onset of senescence. While stratified epithelia such as skin, prostate, and breast are highly… (More)

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