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- Ronald L Willey, Frank M Maldarelli, Malcolm A Martin, Klaus Strebel
- Journal of virology
- 1992
CD4 is an integral membrane glycoprotein which is known as the human immunodeficiency virus (HIV) receptor for infection of human cells. The protein is synthesized in the endoplasmic reticulum (ER)… (More)
- S. Palmer, Ann P Wiegand, +9 authors John M Coffin
- Journal of clinical microbiology
- 2003
More sensitive assays for human immunodeficiency virus type 1 (HIV-1) RNA are needed to detect, quantify, and characterize persistent viremia in patients who are receiving antiretroviral therapy and… (More)
- Sarah E. Palmer, Mary J. Kearney, +11 authors John M Coffin
- Journal of clinical microbiology
- 2005
To investigate the extent to which drug resistance mutations are missed by standard genotyping methods, we analyzed the same plasma samples from 26 patients with suspected multidrug-resistant human… (More)
- Stephen A Migueles, Christine M. Osborne, +25 authors Mark Connors
- Immunity
- 2008
Virus-specific CD8+ T cells probably mediate control over HIV replication in rare individuals, termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive investigation, the… (More)
- Frank M Maldarelli, Xifeng Wu, +9 authors Stephen H. Hughes
- Science
- 2014
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many… (More)
- Rebecca Batorsky, Mary F Kearney, Sarah E. Palmer, Frank M Maldarelli, Igor M. Rouzine, John M Coffin
- Proceedings of the National Academy of Sciences…
- 2011
HIV adaptation to a host in chronic infection is simulated by means of a Monte-Carlo algorithm that includes the evolutionary factors of mutation, positive selection with varying strength among… (More)
- Frank M Maldarelli, Mu Yan Chen, Ronald L Willey, Klaus Strebel
- Journal of virology
- 1993
The human immunodeficiency virus type 1 Vpu protein is a 16-kDa phosphoprotein which enhances the efficiency of virion production and induces rapid degradation of CD4, the cellular receptor for human… (More)
- Galina N. Nikolenko, Krista A Delviks-Frankenberry, +4 authors Vinay K Pathak
- Proceedings of the National Academy of Sciences…
- 2007
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in nucleoside reverse transcriptase inhibitor (NRTI) resistance. To explore the… (More)
- Frank M Maldarelli, Sarah E. Palmer, +15 authors John W Mellors
- PLoS pathogens
- 2007
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1… (More)
- Riri Shibata, Frank M Maldarelli, +5 authors María Ángeles Martín
- The Journal of infectious diseases
- 1997
Chimeric simian-human immunodeficiency viruses (SHIVs) carrying envelope glycoproteins derived from a T cell-macrophage dual-tropic primary isolate (human immunodeficiency virus type 1 [HIV-1] strain… (More)