Frank L Hurley

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CONTEXT Leflunomide is a reversible inhibitor of de novo pyrimidine synthesis shown to be effective in a phase 2 trial in 402 patients with active rheumatoid arthritis (RA). OBJECTIVE To compare the efficacy and safety of leflunomide treatment with placebo and methotrexate treatment in patients with active RA. DESIGN Randomized, double-blind, placebo,(More)
OBJECTIVE To determine whether treatment with leflunomide (LEF), methotrexate (MTX), or sulfasalazine (SSZ) for 6-12 months retards progression of radiographic damage and to identify clinical variables that correlate with radiographic progression. METHODS Radiographs of the hands and feet were performed at baseline and at the end of study or early exit in(More)
OBJECTIVE To examine the relationship between changes in anti-double-stranded DNA (anti-dsDNA) antibody levels and the risk of renal flare in patients with systemic lupus erythematosus (SLE), using data from 2 randomized, controlled trials. METHODS Analyses were based on 487 patients with SLE and a history of lupus nephritis who had an anti-dsDNA antibody(More)
Missing data in controlled clinical trials may create uncertainty in the results of a study based on non-missing data. We used 4 approaches of sensitivity analysis to address this problem. Radiographic progression data were used from a randomized controlled trial of patients with rheumatoid arthritis treated with leflunomide, methotrexate, or placebo for 12(More)
IMPLICATIONS The elimination of potassium in patients with end-stage kidney failure is limited. An increase in potassium concentrations can lead to lethal arrhythmias. In the described case, a large potassium concentration was treated during a liver transplantation using a new technical approach.
OBJECTIVE Five double-blind, randomized, saline-controlled trials (RCTs) were included in the United States marketing application for an intra-articular hyaluronan (IA-HA) product for the treatment of osteoarthritis (OA) of the knee. We report an integrated analysis of the primary Case Report Form (CRF) data from these trials. METHOD Trials were similar(More)
While commencement exercises for the class o! 1932 a r e being held, members of the Rice classes of 1922 and 1927 will meet in reunion at Ye Olde College inn. Both will open their sessions at 12:30 p. m. Monday. The class of 1922 will be celebrating the tenth anniversary of graduation f rom the Rice Institute, while the class of 1927 will commemorate the(More)
The Rice Chapter of the Phi Lambda Upsilon, honorary Chemical Society, is conducting a series of addresses by members of the chapter on scientific subjects. The first of those talks was delivered last WefineSday by Ben F. Frederick on thk sUWMt. of. ^Artificial Radieactivtiy." M ^ B f e t e ' ^ l o y ^ d in pc^iuclpg, arti|^iffl'.racgMctive ' elements 6ftd(More)