Frank Lützenkirchen

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In matrix-assisted laser desorption ionization (MALDI) a large fraction of analyte ions undergo post-source decay (PSD) during flight in the field-free drift path. By means of a modified two-stage reflectron, product ion time-of-flight spectra of medium-sized linear peptides (up to 2800 u) were recorded, containing full sequence information. Precision,(More)
The potential of matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source decay (PSD) time-of-flight mass spectrometry for the characterization of peptides and proteins is discussed. Recent instrumental developments provide for levels of sensitivity and accuracy that make these techniques major analytical tools for proteome analysis. New(More)
In accordance with the European regulation for classification, labelling and packaging of substances and mixtures (CLP) as well as the criteria as set out in the Globally Harmonized System (GHS), fine fraction of crystalline silica (CS) has been classified as a specific target organ toxicity, the specific organ in this case being the lung. Generic cut-off(More)
Ziel des DFG-Projektes mistel ist die Verschmelzung von Systemen zur Erstellung und Organisation von Lehrmaterialien mit Lernumgebungen zur kooperativen Wissensorganisation und digitalen Dokumentenund Publikationsservern. Ein derart föderiertes System mit offenen Schnittstellen bietet in Bildung, Forschung und Wissenschaft die Möglichkeit der Unterstützung(More)
The fragmentation of positive ions of DNA under the conditions of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was investigated by post-source decay (PSD) analysis and hydrogen/deuterium (H/D) exchange. Spectra of five different synthetic 4mer oligonucleotides were recorded. As a main result the hypothesis was confirmed that for(More)
The authors respond to the points raised in the Letters to the Editor raised by Ogden and Du Clos and by Foster. Ad 1: The debate of the classification of respirable cyrstalline silica is outside the scope of the technical paper. Ad 2: A standard for the determination of SWeRF is under development, in which indeed the provision is made that for a correct(More)
Sichtbare Mehrsprachigkeit zeigt sich im öffentlichen Raum auf Hinweis-, Informationsund Geschäftsschilden sowie auf Graffiti und Aufklebern und gibt Aufschluss über Migration, Kulturund Konsumtourismus. Das von MERCUR (Mercator Research Center Ruhr) geförderte Projekt „Metropolenzeichen: Visuelle Mehrsprachigkeit in der Metropole Ruhr“ ist eine als(More)