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BACKGROUND The cysteine proteinases in papaya latex have been shown to have potent anthelmintic properties in monogastric hosts such as rodents, pigs and humans, but this has not been demonstrated in ruminants. METHODS In two experiments, sheep were infected concurrently with 5,000 infective larvae of Haemonchus contortus and 10,000 infective larvae of(More)
One of the more promising automatic storage reclamation techniques, generation scavenging, suffers poor performance if many objects live for a fairly long time and then die. We have investigated the severity of this problem by simulating a two-generation scavenger using traces taken from actual 4-h sessions. There was a wide variation in the sample runs,(More)
The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug(More)
Frank Jackson has given us an elegant and important book. It is, by a long shot, the most sophisticated defense of the use of conceptual analysis in philosophy that has ever been offered. But we also we find it a rather perplexing book, for we can't quite figure out what Jackson thinks a conceptual analysis is. And until we get clearer on that, we're not at(More)
Is non-cognitivism compatible with minimalism about truth? A contemporary argument claims not, and therefore that moral realists, for example, should take heart from the popularity of semantic minimalism. The same is said to apply to cognitivism about other topics—conditionals, for example—for the argument depends only on the fact that ordinary usage(More)
Anthelmintic resistance is a major problem for the control of parasitic nematodes of livestock and of growing concern for human parasite control. However, there is little understanding of how resistance arises and spreads or of the "genetic signature" of selection for this group of important pathogens. We have investigated these questions in the system for(More)