Frank Jackson

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Apart from the obvious role of plants in herbivore nutrition, they are also a rich source of bioactive products that can operate either to the benefit or the detriment of grazing animals. Here, we review the available evidence for the potential beneficial effects that plant-derived bioactive substances can have on gastrointestinal parasites. Tannin-rich(More)
The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug(More)
Many of the Haemonchus contortus isolates currently used for experimental work were originally derived from different regions of the world and are commonly exchanged between laboratories. In most cases, these are largely genetically uncharacterised other than the analyses conducted on specific genes of interest. We have used a panel of eight microsatellite(More)
One of the more promising automatic storage reclamation techniques, generation scavenging, suffers poor performance if many objects live for a fairly long time and then die. We have investigated the severity of this problem by simulating a two-generation scavenger using traces taken from actual 4-h sessions. There was a wide variation in the sample runs,(More)
Anthelmintic resistance is a major problem for the control of parasitic nematodes of livestock and of growing concern for human parasite control. However, there is little understanding of how resistance arises and spreads or of the "genetic signature" of selection for this group of important pathogens. We have investigated these questions in the system for(More)
There is a need to develop tools to study the genetics of parasitic nematodes. This is particularly urgent for those species in which anthelmintic resistance is common such as the sheep parasite Teladorsagia (Ostertagia) circumcincta. The lack of information on the population genetics of such parasites severely limits our ability to study the genetic basis(More)
The increasing prevalence of anthelmintic resistance has provided a spur for research into 'alternative/novel' approaches to the control of helminthoses that are intended to reduce our reliance upon using chemoprophylaxis. The different approaches either target the parasite population in the host or on pasture, but the goal of all of them is to restrict(More)
The state of anthelmintic resistance in Scottish sheep flocks was evaluated during April-August 2000 using in vitro bioassays, egg hatch assays for detecting thiabendazole (TBZ) resistance and larval development assays for levamisole, ivermectin and TBZ resistance. Anaerobic sampling kits and detailed questionnaires outlining farm demographics and current(More)
Goats (caprine) and sheep (ovine) are infected with the same principal gastrointestinal nematode (GIN) species, which provoke similar pathological changes and economic consequences. However, until now, the majority of data on host-parasite interactions have been accumulated from ovine studies. This article aims to emphasize the need for specific caprine(More)
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