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Regulation of swelling-activated Cl(-) current by angiotensin II signalling and NADPH oxidase in rabbit ventricle.
AIMS We assessed whether hypoosmotic swelling of cardiac myocytes activates volume-sensitive Cl(-) current (I Cl,swell) via the angiotensin II (AngII)-reactive oxygen species (ROS) signallingExpand
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Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
AIMS Because ceramide accumulates in several forms of cardiovascular disease and ceramide-induced apoptosis may involve the volume-sensitive Cl(-) current, I(Cl,swell), we assessed whether ceramideExpand
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  • Open Access
Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores
Duchenne muscular dystrophy (DMD) is an X-linked disorder that leads to cardiac and skeletal myopathy. The complex immune activation in boys with DMD is incompletely understood. To better understandExpand
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  • Open Access
Regulation of Volume-Sensitive Chloride Current in Cardiac HL-1 Myocytes
HL-1 cells derived from mouse atrial myocytes retain many features of differentiated adult cardiomyocytes, continuously divide, and are emerging as a useful experimental tool. Features of severalExpand
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Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.
Voltage-gated potassium (Kv) channels control myocardial repolarization. Pore-forming Kvα proteins associate with intracellular Kvβ subunits, which bind pyridine nucleotides with high affinity andExpand
Ceramide Activates ICl,swell in Rabbit Ventricular Myocytes via Mitochondrial ROS Production
We previously showed that ICl,swell is activated by ROS generation via NADPH oxidase (NOX) and the mitochondrial electron transport chain (ETC). Sphingolipid signaling is implicated in channelExpand
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Sphingosine-1-Phosphate Regulates Volume-Sensitive Chloride Current in Ventricular Myocytes by Means of ROS
We previously demonstrated that bacterial sphingomyelinase (SMase) activates a volume-sensitive current, ICl,swell, by a pathway that involves mitochondrial ROS production. SMase activity generatesExpand
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