Frank J Schmidt

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The RNA world scenario posits the existence of catalytic and genetic networks whose reactions are catalyzed by RNAs. Substantial progress has been made in recent years in the selection of RNA catalysts by SELEX, thus verifying one prediction of the model. However, many selected catalysts are long molecules, leading to a question of whether they could have(More)
The domains of large ribozymes are composed of secondary structural elements that fold independently in solution. Interactions between these structures contribute to the overall structure of the ribozyme. These elements can also be deleted, reducing catalytic activity, and their structure-function relationships determined by assaying the ability of variant(More)
We now talk offhandedly of a prebiotic RNA World, a notion that was dismissed as idle and untestable speculation when proposed in the 1960s. Since then, RNA has been shown to catalyze chemical reactions, including the synthesis of the peptide bond. Small RNAs can be selected to recognize compounds with exquisite sensitivity. Even more surprising, some of(More)
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