Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for osteoarthritis due to limited understanding of osteoarthritis pathogenesis. We show that TGF–β1 is activated in the subchondral bone in response to altered mechanical loading in an anterior cruciate ligament transection (ACLT) osteoarthritis mouse… (More)
OBJECTIVE It is important that during preoperative skin preparation surgical site markings are not erased. The effects of 2 common types of skin preparation solutions on surgical site markings were compared. METHODS Fasciocutaneous skin flaps were harvested and 20 random combinations of 3 letters were written on the skin flaps with a black permanent… (More)
receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. Inhibition of TGFβ signaling in subchondral bone mesenchymal stem cells prevents onset of osteoarthritis. with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells. Irradiation induces bone injury by… (More)
Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, regulates bone mass in adulthood. We report that IGF-1 released from bone matrix stimulates osteoblastic differentiation of mesenchymal stem cell (MSCs) by activation of mTOR during bone remodeling. Mice knockout of IGF-1 receptor (Igf1r) in the preosteoblastic cells… (More)
OBJECTIVE To describe a novel method to reconstruct, with a vascularized rotational tibiaplasty, a complex femoral defect in an adolescent. METHODS After a femoral osteosarcoma resection, allograft reconstruction, and chemotherapy, an 11-year-old girl developed recurrent thigh wound infections and femoral allograft osteomyelitis despite multiple operative… (More)
Animals. We obtained Rag –/– mice from the Mouse Models of Human Cancers Consortium Repository, US National Cancer Institute. Igf1r fl/fl and Osx1-GFP:Cre (The Jackson Laboratory) mouse lines have been described previously 22. To generate Osx-Cre; Igf1r fl/fl (Igf1r –/–) mice, we crossed hemizygous Osx-Cre transgenic mice with Igf1r fl/fl mice to generate… (More)
Patient care is the primary focus of the orthopaedic profession. The enhancement of patient care has required and will continue to require orthopaedic surgeons to collaborate productively with industry to develop new medical technology and techniques that improve patient care. The relationship between orthopaedic surgeons and industry is of critical… (More)
Intracortical chondromas are exceedingly rare lesions that have the histopathologic appearance of enchondromas, but are located within cortical bone. Two new cases of intracortical chondroma, one symptomatic and the other found incidentally, are presented and the entity's brief literature reviewed.