Frank Hampel

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A smoothing principle for M-estimators is proposed. The smoothing depends on the sample size so that the resulting smoothed M-estimator coincides with the initial M-estimator when n → ∞. The smoothing principle is motivated by an analysis of the requirements in the proof of the Cramér-Rao bound. The principle can be applied to every M-estimator. A(More)
The kinetic resolution of chiral aminoalkenes by hydroamination-cyclization was studied by using 3,3'-bis(triarylsilyl)-substituted binaphtholate rare-earth-metal complexes. The resolution of 1-arylaminopentenes proceeds with high efficiency and high trans-diastereoselectivity, whereas the resolution process of 1-alkylaminopentenes suffers from decreasing(More)
Chiral 3,3'-bis(trisarylsilyl)-substituted binaphtholate rare earth metal complexes (R)-[Ln{Binol-SiAr3}(o-C6H4CH2NMe2)(Me2NCH2Ph)] (Ln = Sc, Lu, Y; Binol-SiAr3 = 3,3'-bis(trisarylsilyl)-2,2'-dihydroxy-1,1'-binaphthyl; Ar = Ph (2-Ln), 3,5-xylyl (3-Ln)) and (R)-[La{Binol-Si(3,5-xylyl)3}{E(SiMe3)2}(THF)2] (E = CH (4a), N (4b)) are accessible via facile arene,(More)
Copper(I) and copper(II) complexes possessing a series of related ligands with pyridyl-containing donors have been investigated. The ligands are tris(2-pyridylmethyl)amine (tmpa), bis[(2-pyridyl)methyl]-2-(2-pyridyl)ethylamine (pmea), bis[2-(2-pyridyl)ethyl]-(2-pyridyl)methylamine (pmap), and tris[2-(2-pyridyl)ethyl]amine (tepa). The crystal structures of(More)
In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard drugs, we present the synthesis and biological investigations of 2nd generation 1,2,4-trioxane-ferrocene hybrids. In vitro tests against the CCRF-CEM leukemia cell line(More)
Three new unsymmetrical anthracenyl-pentacene derivatives have been synthesized, characterized using X-ray crystallography, and used as semiconductors in OTFTs. For one derivative, ambipolar charge carrier transport was observed with a hole mobility of 0.2 cm(2) V(-1) s(-1) and an electron mobility of 0.03 cm(2) V(-1) s(-1).
The background of the paper is the empirical fact that the fundamental assumption of independence in statistics is generally false and has to be replaced by long-range dependence. Since this is far from generally known, some evidence of it is reviewed. It can easily be seen that long-range dependence has disastrous eeects on the naive statistical treatment(More)
We report here on the selective synthesis of fullerene pentakisadducts 3 with an incomplete octahedral addition pattern by means of mixed [5:1]hexakisadducts 1 that involve an isoxazoline moiety as a protection group. The isoxazoline addend can be cleanly cleaved by irradiation with light. By using this protection-deprotection strategy, a variety of(More)
A limited but basic problem in the foundations of statistics is the following: Given a parametric model, given perhaps some observations from the model, but given no prior information about the parameters (“total ignorance”), what can we say about the occurrence of a specified event A under this model in the future (prediction problem)? Or, as probabilities(More)
The paper describes the proper interpretation of the fiducial argument, as given by Fisher in (only) his first papers on the subject. It argues that far from being a quaint, little, isolated idea, this was the first attempt to build a bridge between aleatory probabilities (the only ones used by Neyman) and epistemic probabilities (the only ones used by(More)