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Herniated intervertebral disc tissue has been shown to produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain. We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E2 (PGE2) in disc tissue from patients(More)
STUDY DESIGN Retrospective review of patient records, clinical and radiographic, and patient recall for full pulmonary function studies and surface topography. OBJECTIVES Assessment of outcome of treatment policy after age 15 during the previous 30 years to establish the efficacy of management protocols in a group that is too small and too varied for more(More)
STUDY DESIGN Disc tissue obtained from patients undergoing surgery for scoliosis, lumbar radiculopathy, and discogenic pain was cultured under basal and lipopolysaccharide-stimulated conditions and the medium analyzed for production of a range of pro-inflammatory mediators. OBJECTIVES This study was conducted to confirm that the human intervertebral disc(More)
STUDY DESIGN Analysis of scoliosis screening in Dublin (1979-1990) of patients who passed significant levels (25 degrees and 40 degrees) and received orthotic treatment or surgery. OBJECTIVES To reexamine the basis of school scoliosis screening. SUMMARY OF BACKGROUND DATA The United States Preventive Services Task Force questioned the validity of school(More)
Hurler's syndrome is an autosomal recessive metabolic storage disease with distinct skeletal manifestations, which include progressive hip dislocation. Enzyme-replacement therapy by bone marrow transplantation improves life expectancy but does not prevent hip dislocation. We describe the features of hip dysplasia in a series of eight successfully engrafted(More)
Hurler syndrome is an autosomal recessive metabolic storage disease. Hematopoietic stem cell transplant increases life expectancy, but the effects on associated musculoskeletal abnormalities remains unclear, and long-term data are limited. We detail the follow-up of 23 patients at a mean of 8.5 years after successful hematopoietic stem cell transplant. All(More)
A 12 year retrospective review provides a group of 68 children with pelvic fractures. The distribution and type of fractures are similar to those of adults. The most common aetiology is an automobile-pedestrian accident. The average age is 8 years; male patients are nearly twice as common. Over 73 per cent are stable injuries. The fractures rarely occurred(More)
STUDY DESIGN Retrospective analysis of outcome in terms of incidence of surgery for adolescent idiopathic scoliosis during a period when bracing was not practiced. OBJECTIVES To determine whether centers with an active bracing policy have lower numbers undergoing surgery for adolescent idiopathic scoliosis than a center where nonintervention is the(More)
STUDY DESIGN Preliminary analysis of the clinical value of surface topography in a spinal deformity clinic. OBJECTIVES The Cobb angle is the gold standard for the monitoring of scoliosis. This study was designed to determine whether surface topography would reflect Cobb angle status with sufficient reliability to permit its safe use as an alternative(More)
STUDY DESIGN Scoliotic and herniated human intervertebral disc tissue obtained intraoperatively was cultured, and the medium was analyzed for the production of monocyte chemoattractant protein-1 and interleukin-8. OBJECTIVES This study was conducted to determine whether the human intervertebral disc is capable of spontaneous production of the chemokines(More)