Frank Dressler

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OBJECTIVE B cells have been shown to play an important role in the pathogenesis of rheumatoid arthritis and juvenile idiopathic arthritis (JIA). Current treatments include the disease-modifying antirheumatic drugs methotrexate (MTX) and tumor necrosis factor α inhibition with etanercept. This study was undertaken to determine how these drugs influence the B(More)
BACKGROUND Most data for treatment of dermatomyositis and juvenile dermatomyositis are from anecdotal, non-randomised case series. We aimed to compare, in a randomised trial, the efficacy and safety of prednisone alone with that of prednisone plus either methotrexate or ciclosporin in children with new-onset juvenile dermatomyositis. METHODS We did a(More)
Aims 1)To investigate the clinical phenotypes and demographic characteristics of affected sibling pairs (ASPs) with juvenile idiopathic arthritis (JIA) 2)To provide an international resource of JIA DNA samples and a base of knowledge from which all genes contributing to the pathogenesis of JIA can be identified. Methods This is a cross-sectional(More)
Three pediatric patients with different illnesses leading to knee arthritis and large Baker cysts and additional calf swelling are reported. Calf swelling was due to true popliteal venous thrombosis and not to the much more common cause of pseudothrombophlebitis. Careful ultrasound examination can differentiate these two causes of calf swelling. Even though(More)
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