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OBJECTIVE To assess the possible toxicity of thimerosal-containing vaccines (TCVs) among infants. METHODS A 2-phased retrospective cohort study was conducted using computerized health maintenance organization (HMO) databases. Phase I screened for associations between neurodevelopmental disorders and thimerosal exposure among 124 170 infants who were born(More)
BACKGROUND It has been hypothesized that early exposure to thimerosal, a mercury-containing preservative used in vaccines and immune globulin preparations, is associated with neuropsychological deficits in children. METHODS We enrolled 1047 children between the ages of 7 and 10 years and administered standardized tests assessing 42 neuropsychological(More)
OBJECTIVE Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD). This study was designed to examine relationships between prenatal and infant ethylmercury exposure from thimerosal-containing vaccines(More)
OBJECTIVES To evaluate suggested associations between childhood vaccinations, particularly against hepatitis B and Haemophilus influenzae type b, and risk of developing type 1 diabetes; and to determine whether timing of vaccination influences risk. METHODS We conducted a case-control study within 4 health maintenance organizations (HMOs) that participate(More)
The Vaccine Safety Datalink is a collaborative project involving the National Immunization Program of the Centers for Disease Control and Prevention and several large health maintenance organizations in the USA. The project began in 1990 with the primary purpose of rigorously evaluating concerns about the safety of vaccines. Computerized data on(More)
BACKGROUND Several case reports of the onset or exacerbation of multiple sclerosis or other demyelinating conditions shortly after vaccination have suggested that vaccines may increase the risk of demyelinating diseases. OBJECTIVE To evaluate the association between vaccination and onset of multiple sclerosis or optic neuritis. DESIGN Case-control study(More)
CONTEXT Beginning with the winter season of 2004-2005, influenza vaccination has been recommended for all children 6 to 23 months old in the United States. However, its safety in young children has not been adequately studied in large populations. OBJECTIVE To screen for medically attended events in the clinic, emergency department, or hospital after(More)
BACKGROUND Two doses of trivalent inactivated influenza vaccine (TIV) are recommended for children <9 years old receiving vaccine for the first time, but compliance is suboptimal. This study assessed the need for a second dose of TIV in this age group. METHODS In this prospective, open-label study, 232 influenza vaccine-naive 5-8-year-olds enrolled in a(More)
BACKGROUND A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations. METHODS The authors conducted a nested case-control study within the General Practice Research Database (GPRD) in the United Kingdom. The(More)