Frank Claessens

Sort by:

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

Karel de Gendt, Johannes V Swinnen, +12 authors Guido Verhoeven
Proceedings of the National Academy of Sciences…
2004

Androgens control spermatogenesis, but germ cells themselves do not express a functional androgen receptor (AR). Androgen regulation is thought to be mediated by Sertoli and peritubular myoid cells,… (More)

Structural basis of androgen receptor binding to selective androgen response elements.

Paul L. Shaffer, Arif Jivan, D Eric Dollins, Frank Claessens, Daniel T Gewirth
Proceedings of the National Academy of Sciences…
2004

Steroid receptors bind as dimers to a degenerate set of response elements containing inverted repeats of a hexameric half-site separated by 3 bp of spacer (IR3). Naturally occurring selective… (More)

Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains.

Erik Schoenmakers, Philippe Alen, +4 authors Frank Claessens
The Biochemical journal
1999

The androgen and glucocorticoid hormones evoke specific in vivo responses by activating different sets of responsive genes. Although the consensus sequences of the glucocorticoid and androgen… (More)

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.

Guy Eelen, Lieve Verlinden, +7 authors Annemieke Verstuyf
Molecular pharmacology
2005

Two 14-epi-analogs of 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D(3)], 19-nor-14-epi-23-yne-1,25-(OH)2D3 (TX522) and 19-nor-14,20-bisepi-23-yne-1,25-(OH)2D3 (TX527), show enhanced antiproliferative (at… (More)

Sex steroid actions in male bone.

D Vanderschueren, Michaël R Laurent, +5 authors C Ohlsson
Endocrine reviews
2014

Sex steroids are chief regulators of gender differences in the skeleton, and male gender is one of the strongest protective factors against osteoporotic fractures. This advantage in bone strength… (More)

The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor.

Annemie Haelens, Tamzin Tanner, Sarah Denayer, Leen Callewaert, Frank Claessens
Cancer research
2007

The androgen receptor (AR) encoding gene can undergo mutations during the development and treatment of prostate cancer. Even in hormone-independent stages, mutations in the receptor paradoxically… (More)

Looking at nuclear receptors from a new angle

Christine Helsen, Frank Claessens
Molecular and Cellular Endocrinology
2014

While the structures of the DNA- and ligand-binding domains of many nuclear receptors have been determined in great detail; the mechanisms by which these domains interact and possibly 'communicate'… (More)

The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1.

Charlotte L Bevan, Susan Hoare, Frank Claessens, David M Heery, Malcolm G. Parker
Molecular and cellular biology
1999

The androgen receptor is unusual among nuclear receptors in that most, if not all, of its activity is mediated via the constitutive activation function in the N terminus. Here we demonstrate that… (More)

The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription.

Philippe Alen, Frank Claessens, Guido Verhoeven, Wilfried Rombauts, Ben Peeters
Molecular and cellular biology
1999

Steroid receptors are conditional transcription factors that, upon binding to their response elements, regulate the expression of target genes via direct protein interactions with transcriptional… (More)

Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men

Sabine M. P. Verschueren, Evelien Gielen, +9 authors Steven Boonen
Osteoporosis International
2012

The aim of this study was to determine the relationship between reduced muscle mass (sarcopenia) and areal bone mineral density (BMDa) in middle-aged and elderly community-dwelling European men. Men… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences