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The hormone progesterone is readily converted to 3alpha-OH-5alpha-pregnan-20-one (3alpha,5alpha-THP) in the brains of males and females. In the brain, 3alpha,5alpha-THP acts like a sedative, decreasing anxiety and reducing seizure activity, by enhancing the function of GABA (gamma-aminobutyric acid), the brain's major inhibitory neurotransmitter. Symptoms(More)
In the present study, we have characterized properties of steroid withdrawal using a pseudopregnant rat model. This paradigm results in increased production of endogenous progesterone from ovarian sources and as such is a useful physiological model. "Withdrawal" from progesterone induced by ovariectomy on day 12 of pseudopregnancy resulted in increased(More)
RATIONALE Neuropsychological impairments seen in depression may be secondary to hypercortisolaemia. Repeated cortisol administration impairs episodic memory with an alteration in event-related potentials (ERPs) recorded during information retrieval. It is unclear whether such ERP effects are specific to episodic memory, or whether repeated cortisol(More)
In this study, we characterized the local effects of ethanol (EtOH) on postsynaptic potentials (PSPs) and membrane properties of layer II-III (L2-3) and layer V (L5) somatosensory cortical neurons. Intracellular recordings were done using the in vitro slice preparation of rat somatosensory cortex. Our results show that EtOH exerts local effects on cortical(More)
17 beta-oestradiol (E2) is known to exert activating effects on CNS excitability, which are in part mediated by increases in glutamate responses, as we have shown in cerebellum. In addition, this steroid is known to facilitate rapid, rhythmic limb movement. Because the inferior olive is believed to be a timer of rapid movement, we have investigated effects(More)
This paper reviews the structured design concept and conventional diagnostic methods. It presents an alternate approach, called structured-trace method, for diagnosing failures on high level packages, which are structurally designed, such as LSSD structure. Implications of structured designs on failure diagnosis are discussed. Results from an evaluation(More)
In the present study we propose a multipoint approach, for the mapping of genes, that is based on the case-parent trio design. We first derive an expression for the expected preferential-allele-transmission statistics for transmission, from either parent to an affected child, for an arbitrary location within a chromosomal region demarcated by several(More)
This paper proposes a testing and diagnostic method that reduces fault location and repair costs on printed circuit boards populated with LSI and VLSI modules. The method requires some additional circuitry on the module subassembly. It enhances the following test strategies: automatic probing, bed-of-nails, Subassembly-in-Place, and Level Sensitive to Scan(More)
The problems arising from the use of nonlinear multipliers in multilayer neural network synapse structures are discussed. The errors arising from the neglect of nonlinearities are shown and the effect of training in eliminating these errors is discussed. A method for predicting the final errors resulting from nonlinearities is described. Our approximate(More)