Frank B. Lacy

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BACKGROUND Oxygen free radicals may play roles in hypertension both in arteriolar constriction and in formation of lesions. OBJECTIVE To quantify free radical production in blood plasma of genetic hypertensives. DESIGN Hydrogen peroxide levels were measured, because it is one of the most stable reactive oxygen species. METHODS An electrode technique(More)
Oxygen free radicals, including hydrogen peroxide, may mediate oxidative stress in target organ tissues and contribute to cardiovascular complications in hypertension. To examine heritability of hydrogen peroxide production, we investigated this trait in a family-based cohort consisting of family members (n=236) ascertained through probands (n=57) with(More)
Enhanced production of oxygen free radicals may play a role in hypertension by affecting vascular smooth muscle contraction, resistance to blood flow, and organ damage. The aim of this study was to determine whether oxygen free radicals are involved in the development of salt-induced hypertension. Dahl salt-sensitive (Dahl-S) and salt-resistant (Dahl-R)(More)
Recently we demonstrated potassium secretion by the pars recta or by the descending limb of the juxtamedullary nephron. The purpose of this present investigation is to study the effect of a chronic high-potassium intake on this phenomenon. Fractional reabsorption of water and sodium by the juxtamedullary proximal nephron was decreased when compared to that(More)
Increased production of oxygen free radicals may play a role in many diseases such as hypertension. As evidence indicates that xanthine oxidase may be involved in creating these reactive oxygen species, experiments were performed to additionally characterize hydrogen peroxide (H2O2) production in xanthine oxidase catalyzed reactions. In vitro measurements(More)
LA. JAM& Renal junction in the chinchilla. Am. J. Physiol. 229(6): 1706-1713. 1970.-Micropuncture and other techniques were used to study renal function in the Chinchilla lanigej*, a species of rodent able to produce a highly concentrated urine. Urine osmolality ranged from 2,350 to 7,599 mOsm after water deprivation and decreased to a mean of 130 mOsm(More)
Vasa recta blood was sampled from the exposed renal papillae of 11 Munich-Wistar rats (Group I). The mean vasa recta plasma-to-systemic plasma (VR/P) inulin concentration ratio was 5.4±1.2 (SE), which is significantly higher than the mean VR/P protein ratio previously reported (1.74 in descending vasa recta and 1.38 in acending vasa recta). Even if(More)