Frank Allen Ferrell

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The kinetics of inhibition by amiloride of the integrated chorda tympani response were investigated in rats subjected to lingual stimulation with NaCl. In one series of experiments the time of exposure to amiloride was varied at fixed amiloride concentration. Exposure to 10(-4) M amiloride for 2 s reduced the response to 0.5 M NaCl by approximately 50%. The(More)
It has been suggested that one risk factor in the development of hypertension and vascular disease may be abnormal copper and zinc metabolism. In the current study we tested the hypothesis that hypertension itself may result in alterations in the metabolism of these essential elements. Dahl salt-sensitive rats were fed diets containing 0.4 or 8.0% NaCl for(More)
Patients with social phobia who responded well to 6 months of open-label treatment with clonazepam were assigned to receive either continuation treatment (CT) with clonazepam for another 5 months, or to undergo discontinuation treatment (DT) using a clonazepam taper at the rate of 0.25 mg every 2 weeks, with double-blind placebo substitution. Clinical(More)
We examined the number and distribution of ganglion cells within a vallate papilla from a healthy human adult. The vast majority of cell bodies were located near the base of the papilla, clustered in the central portion of its core immediately above underlying muscles and von Ebner's glands. Neurons appeared to be of one morphological type with ovoid cell(More)
We determined the course of myelination of the chorda tympani in rats aged from 4- to 30-days-old, the interval of the most rapid developmental changes in neurophysiological taste responses and behavioral discrimination among chemical stimuli. The overall number of axons in rats aged from 16- to 30-days-old and in mature 120-day-old animals were the same(More)
Two-bowl choice tests were used to examined preference of puppies aged two to four months for compounds tasting sweet to humans. Puppies found many, but not all of the compounds highly palatable, and were sensitive to both type and amount of sugar or nonnutritive sweetener contained in a semi-moist dog food recipe. Lactose, fructose, and sucrose were well(More)
To determine whether age-related changes in salt preferences occur over the lifespans of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), the same animals of each genotype were tested as juveniles, and as young and older adults. Taste preference ratios for NaCl and KCl, at concentrations from 0.001 to 1.0 M, were calculated using 24-hour,(More)
Light microscopy and scanning electron microscopy were used to examine tongues of beagle puppies at 38, 47, and 54 days of gestation (term = 63 days) and at postnatal ages ranging from birth to adulthood, to follow the time course of morphological maturation of the papillae and taste buds. Fungiform and circumvallate papillae were present on the 38th fetal(More)
Sugars were used as stimuli to investigate developmental changes in neural gustatory response in puppies from birth to weaning age. Chorda tympani nerve responses to chemical stimulation of the tongue were present at birth. No developmental changes were detected between birth and weaning, and the relative stimulatory effectiveness of six sugars in the(More)
Four experiments investigated the effects of restricting the dietary flavor experience of preweaned puppies on their postweaning preference for the assigned flavor. Each study employed two matched litters of beagles, exposing each litter to a distinctly flavored commercially available dog food before weaning and assessing postweaning preference in two-bowl(More)