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  • Kaamar Azijli, B Weyhenmeyer, Godefridus J. Peters, Steven de Jong, Frank A. E. Kruyt
  • Biology, Medicine
  • Cell Death and Differentiation
  • 2013 (First Published: 1 July 2013)
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However, besides activatingContinue Reading
    We have previously reported that the microtubule stabilizing agents (MSAs) paclitaxel, epothilone B and discodermolide induce caspase-independent cell death in non-small cell lung cancer (NSCLC)Continue Reading
  • Bodvaël Pennarun, Annemieke Meijer, Elisabeth G.E. de Vries, Jan H. Kleibeuker, Frank A. E. Kruyt, Steven de Jong
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2010 (First Published: 1 April 2010)
  • Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its twoContinue Reading
  • Maarten L. Janmaat, Frank A. E. Kruyt, José Antonio Rodríguez, Giuseppe Giaccone
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2003 (First Published: 1 June 2003)
  • The epidermal growth factor receptor (EGFR) is an important novel target for anticancer therapy. In this study, we examined the molecular mechanisms that underlie the antitumor effects of theContinue Reading
  • Maarten L. Janmaat, José Antonio Rodríguez, Mariëlle I Gallegos-Ruiz, Frank A. E. Kruyt, Giuseppe Giaccone
  • Medicine
  • International journal of cancer
  • 2006 (First Published: 1 May 2006)
  • In this study, we have characterized a panel of NSCLC cell lines with differential sensitivity to gefitinib for activating mutations in egfr, pik3ca, and k-ras, and basal protein expression levels ofContinue Reading
  • José Antonio Rodríguez, Simone W. Span, Carlos Gil Ferreira, Frank A. E. Kruyt, Giuseppe Giaccone
  • Biology, Medicine
  • Experimental cell research
  • 2002 (First Published: 15 April 2002)
  • Survivin is a member of the inhibitor of apoptosis (IAP) family of negative regulators of programmed cell death that is frequently overexpressed in human tumors. Survivin is not only involved in theContinue Reading
  • Cynthia Huisman, Carlos Renê Gomes Ferreira, +5 authors Giuseppe Giaccone
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2002 (First Published: 1 February 2002)
  • PURPOSE Here we report on the role of mitochondria, death receptors (DRs), and caspases in exerting the cytotoxic effect of clinically relevant concentrations of paclitaxel in the non-small cell lungContinue Reading