Frank A Alexander

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The use of 3-D multicellular spheroid (MCS) models is increasingly being accepted as a viable means to study cell-cell, cell-matrix and cell-drug interactions. Behavioral differences between traditional monolayer (2-D) cell cultures and more recent 3-D MCS confirm that 3-D MCS more closely model the in vivo environment. However, analyzing the effect of(More)
Silica nanowires have great potential for usage in the development of highly sensitive in vivo biosensors used for biomarker monitoring. However, careful analysis of nanowire toxicity is required prior to placing these sensors within the human body. This paper describes a real-time and quantitative analysis of nanowire cytotoxicity using impedance(More)
EBNA-1 is the only viral protein consistently expressed in all cells latently infected by Epstein-Barr virus (EBV). There is a high frequency of sequence variation within functionally important domains of EBNA-1, with five subtypes identified. Individuals may be infected with multiple EBV strains (classified according to EBNA-1 subtype), but Burkitt's(More)
This paper reports the design and evaluation of a multi-electrode design that improves upon the statistical significance and spatial resolution of cellular impedance data measured using commercial electric cell-substrate impedance sensing (ECIS) systems. By evaluating cellular impedance using eight independent sensing electrodes, position-dependent(More)