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The mammalian inner ear contains two sensory organs, the cochlea and vestibule. Their sensory neuroepithelia are characterized by a mosaic of hair cells and supporting cells. Cochlear hair cells differentiate in four rows: a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs). Recent studies have shown that Math1, a mammalian(More)
Three different aptitudes involved in sound object recognition were tested in 60 normal subjects and 20 brain-damaged patients: (i) capacity to segregate sound objects on different cues (intensity steps, coherent temporal modulations or signal onset synchrony); (ii) asemantic recognition of sounds of real objects by judging whether two different sound(More)
Hearing loss can be caused by a variety of insults, including acoustic trauma and exposure to ototoxins, that principally effect the viability of sensory hair cells via the MAP kinase (MAPK) cell death signaling pathway that incorporates c-Jun N-terminal kinase (JNK). We evaluated the otoprotective efficacy of D-JNKI-1, a cell permeable peptide that blocks(More)
Single unit spike trains were recorded in the auditory cortex (n = 78) and in the auditory thalamus (n = 55) of nitrous oxide anesthetized cats. The electrophysiological activity was studied before and during the application of pentobarbital (P, 7 mg/kg), ketamine (K, 12 mg/kg) and a mixture of these anesthetics (KP). The units were characterized during the(More)
The response properties to clicks, noise and tone bursts of 2152 single units located in the ventral division of the medial geniculate body were analysed as a function of their anatomical position. A particular spatial distribution of these properties was observed in the pars lateralis (LV) and ovoidea (OV). The distribution of different response(More)
The development of the mammalian cochlea is an example of patterning in the peripheral nervous system. Sensory hair cells and supporting cells in the cochlea differentiate via regional and cell fate specification. The Notch signaling components shows both distinct and overlapping expression patterns of Notch1 receptor and its ligands Jagged1 (Jag1) and(More)
In this paper we studied the morphology and spatial distribution of corticothalamic axons and terminals originating from the auditory cortical fields of the cat. The anterograde tracer biocytin was injected at electrophysiologically characterized loci in the primary (AI) (N = 2), anterior (AAF) (N = 1), posterior (PAF) (N = 1) and secondary (AII) (N = 2)(More)
The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic frequencies (CF) was observed along(More)