Franco Veglio

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Hypertension is associated with cardiovascular risk and systemic target organ damage. Retinopathy is considered one of the indicators of target organ damage. This review focuses on recent studies on hypertensive retinopathy and their implications for clinical care. Early recognition of hypertensive retinopathy signs remains an important step in the risk(More)
—We investigated the expression of ␣ 1-adrenergic receptor subtypes in intact human peripheral blood lympho-cytes using reverse transcription–polymerase chain reaction (RT-PCR) and radioligand binding assay techniques combined with antibodies against the three subtypes of ␣ 1-adrenergic receptors (␣ 1A , ␣ 1B , and ␣ 1D). RT-PCR amplified in peripheral(More)
The presence and the pharmacological profile of dopamine D3 receptor have been investigated in human peripheral blood lymphocytes using radioligand binding techniques and the selective dopamine D3 receptor agonist [3H]7-hydroxy-N,N-di-n-pro-pyl-2-aminotetralin ([3H]7-OH-DPAT) as a ligand. [3H]7-OH-DPAT binding to human peripheral blood lymphocytes was(More)
Numerous studies conducted in recent years have reported an increase in the prevalence of primary aldosteronism (PA). This increase has arisen because of changes in our screening methods used to detect PA, notably the widespread use of the ratio of plasma aldosterone concentration to plasma renin activity. A positive screening result, however, is not(More)
Hypertension is a risk factor for stroke and may also contribute to the development of vascular cognitive impairment (VCI) and vascular dementia (VaD). Cognitive complications of hypertension and the influence of anti-hypertensive treatment were underestimated until recently. In this paper, trials investigating the effect of anti-hypertensive treatment on(More)
BACKGROUND Scarce data are available on the influence of psychological aspects on 24-hour ambulatory blood pressure patterns either in normotensive or hypertensive subjects. This study was designed to evaluate the relationship between psychological profile and changes in daytime/nighttime blood pressure rhythm. METHODS Nocturnal dipping was defined as the(More)
There is general consensus on the use of (but not cut-off values for) the aldosterone/plasma renin activity ratio as a screening test for primary aldosteronism. There is also agreement on the need for subsequent confirmatory testing, but not on the protocols to be chosen. The four most common confirmatory tests in clinical practice are oral sodium loading,(More)
Adrenal glands removed for unilateral primary aldosteronism (PA) display marked histological heterogeneity. Recently reported somatic mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D can partially account for these differences. In this study we aimed at combining phenotypic and genotypic characteristics, integrating genetic and immunohistochemistry correlates(More)
INTRODUCTION Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice. AIM The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of(More)
The pharmacological characteristics and the anatomical localization of dopamine D1-like and D2-like receptors were studied in sections of the human adrenal cortex using radioligand binding and autoradiographic techniques. [3H]SCH 23390 was used as a ligand of D1-like receptors, whereas [3H]spiroperidol was used to label D2-like receptors. No specific(More)