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BACKGROUND TGF-β1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-β1 binds to the latent TGF-β1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM). Transmission of cell force via integrins is one major mechanism to(More)
The laminar distribution of flash evoked field potential (VEP) was investigated in the visual cortical areas 17 and 18 b in freely moving rats. Averaged VEPs were recorded during stable relaxed wakefulness characterized behaviorally and polygraphically. The depth profiles of the main VEP components displayed polarity reversals in lamina V in every electrode(More)
Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the extracellular matrix (ECM). Mechanical activation of TGF-β1 is currently understood as an acute process that depends on the contractile force of cells. However, we show that ECM remodeling, preceding(More)
Active avoidance learning, retention and relearning were investigated before and after lesions of the interpeduncular nucleus (IP) of rat in a Y-maze and a jump test box. Preoperatively learnt active avoidance was abolished after the lesions and rats were not able to relearn it. Unconditioned escape responses remained unchanged in the Y-maze. Postoperative(More)
Simple reaction times (RT) to clicks, flashes and numerical signals were measured in four groups of subjects: 21 patients with mild presenile onset dementia of the Alzheimer type (PDAT, mean age 56 years), 14 patients with chronic cardiovascular disease and incipient cognitive deficit (mean age 55 years), 15 healthy older controls (mean age 53 years) and 16(More)
Acoustically evoked potentials (AEP) were recorded and analysed in the basal forebrain (bf, nucleus basalis magnocellularis) and in the mesencephalic parabrachial nucleus cuneiformis (Cnf) of freely moving rats and the modulatory effects of electrical single stimulations within both cholinergic regions on these AEP are described. Bipolar electrodes were(More)
Adult male hooded rats of the Long-Evans strain were investigated before and after lesions of the ventral nucleus reticularis pontis oralis (vRPO) in an open field test (OF) and in a Y-maze. The OF and the neurological findings were scarcely changed. Startle responses were strongly reduced and also horizontal head and body turning in the OF were(More)
The postnatal development of open field (OF) behaviour of two groups of each 8 male hooded rats (Long-Evans strain) was compared after bilateral eye bulb removal on the seventh postnatal day (pd) in one group and sham-operation on the same day in the other group. Ambulatory activity of the deprived group was much increased (p less than 0.01) in all sessions(More)
Hooded rats of the Long-Evans strain with bilateral symmetric lesions of the nucleus reticularis pontis oralis (RPO) displayed locomotor hyperactivity in the open field (OF) compared with their preoperative values. Their locomotor velocity and their climbing rate were significantly enhanced. Habituation in the OF was significantly weakened. The lesioned(More)
Differences in inducing behavioural activation of two different cholinergic brain regions, the basal forebrain (nucleus basalis magnocellularis) and the mesencephalic nucleus cuneiformis were investigated in freely moving rats with electrodes in the hippocampus, the frontal cortex and olfactory bulb. Serial electrical stimulations with increasing(More)