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Antitumor effect of novel berberine derivatives in breast cancer cells.

• Elisa Pierpaoli, Andrea G Arcamone, Franco Buzzetti, Paolo Lombardi, Carmela Salvatore, Mauro Provinciali
• BioFactors
• 2013

Breast cancer is the most common malignancy and the most common cause of cancer death in elderly women. Chemoprevention with dietary compounds and their synthetic analogs has emerged as an attractive… (More)

Spectroscopic studies on the binding interaction of novel 13-phenylalkyl analogs of the natural alkaloid berberine to nucleic acid triplexes.

• Debipreeta Bhowmik, Franco Buzzetti, Gaetano Fiorillo, Paolo Lombardi, Gopinatha Suresh Kumar
• Spectrochimica acta. Part A, Molecular and…
• 2014

In this study we have characterized the capability of six 13-phenylalkyl analogs of berberine to stabilize nucleic acid triplex structures, poly(rA)⋅2poly(rU) and poly(dA)⋅2poly(dT). Berberine… (More)

Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding.

• Debipreeta Bhowmik, Maidul Hossain, Franco Buzzetti, Rosaria D'Auria, Paolo Lombardi, Gopinatha Suresh Kumar
• The journal of physical chemistry. B
• 2012

The structural effects and thermodynamics of the DNA binding of six berberine analogues with alkyl chains of varying length and a terminal phenyl group at the C-13 position were investigated. All the… (More)

Effect of new berberine derivatives on colon cancer cells.

• Luis Miguel Guamán Ortiz, Anna Leta Croce, +6 authors Anna Ivana Scovassi
• Acta biochimica et biophysica Sinica
• 2015

The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized… (More)

Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB.

• Sara D Vieira, Silvia Castelli, +5 authors Alessandro Desideri
• International journal of biological…
• 2015

Topoisomerases IB are anticancer and antimicrobial targets whose inhibition by several natural and non-natural compounds has been documented. The inhibition effect by berberine and some… (More)

Multiple Effects of Berberine Derivatives on Colon Cancer Cells

• Luis Miguel Guamán Ortiz, Micol Tillhon, +7 authors Anna Ivana Scovassi
• BioMed research international
• 2014

The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit… (More)

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