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- Publications
- Influence
Effect of new berberine derivatives on colon cancer cells.
- L. M. Guamán Ortiz, A. L. Croce, +6 authors A. Scovassi
- Biology, Medicine
- Acta biochimica et biophysica Sinica
- 1 October 2015
The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized… Expand
Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding.
- D. Bhowmik, Maidul Hossain, Franco Buzzetti, Rosaria D'Auria, P. Lombardi, G. S. Kumar
- Chemistry, Medicine
- The journal of physical chemistry. B
- 10 February 2012
The structural effects and thermodynamics of the DNA binding of six berberine analogues with alkyl chains of varying length and a terminal phenyl group at the C-13 position were investigated. All the… Expand
Multiple Effects of Berberine Derivatives on Colon Cancer Cells
- L. M. Guamán Ortiz, Micol Tillhon, +7 authors A. Scovassi
- Biology, Medicine
- BioMed research international
- 18 June 2014
The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit… Expand
Antitumor effect of novel berberine derivatives in breast cancer cells.
- E. Pierpaoli, Andrea G Arcamone, Franco Buzzetti, P. Lombardi, C. Salvatore, M. Provinciali
- Biology, Medicine
- BioFactors
- 1 November 2013
Breast cancer is the most common malignancy and the most common cause of cancer death in elderly women. Chemoprevention with dietary compounds and their synthetic analogs has emerged as an attractive… Expand
New 13-pyridinealkyl berberine analogues intercalate to DNA and induce apoptosis in HepG2 and MCF-7 cells through ROS mediated p53 dependent pathway: biophysical, biochemical and molecular modeling…
- S. Chatterjee, Sumana Mallick, +5 authors G. S. Kumar
- Chemistry
- 22 October 2015
A new series of 13-pyridinealkyl berberine analogues was synthesized and their DNA binding efficacy studied by employing spectroscopic, calorimetric and molecular modeling techniques. Analogues with… Expand
Synthesis of new 13-diphenylalkyl analogues of berberine and elucidation of their base pair specificity and energetics of DNA binding
- D. Bhowmik, Franco Buzzetti, +4 authors G. S. Kumar
- Chemistry
- 29 January 2014
A series of 13-diphenylalkyl berberine derivatives were designed and synthesized, and their base specificity and energetics of DNA binding were evaluated using one natural and two synthetic DNA… Expand
Spectroscopic studies on the binding interaction of novel 13-phenylalkyl analogs of the natural alkaloid berberine to nucleic acid triplexes.
- D. Bhowmik, Franco Buzzetti, G. Fiorillo, P. Lombardi, G. Suresh Kumar
- Chemistry, Medicine
- Spectrochimica acta. Part A, Molecular and…
- 24 February 2014
In this study we have characterized the capability of six 13-phenylalkyl analogs of berberine to stabilize nucleic acid triplex structures, poly(rA)⋅2poly(rU) and poly(dA)⋅2poly(dT). Berberine… Expand