Franck J. D. Mennechet

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In humans, type I interferon (IFN) is a family of 17 cytokines, among which the alpha subtypes and the beta subtype are differentially expressed. It has been suggested that IFN-beta activates a specific signaling cascade in addition to those activated by all type I IFNs. Nevertheless, no true biological relevance for a differential activity of alpha and(More)
The lambda interferons (IFN-lambdas), also known as IL-28 and IL-29, are coexpressed with IFN-beta after Toll-like-receptor (TLR) stimulation in human monocyte-derived dendritic cells (DCs). IFN-lambda shares with type I IFNs an intracellular signaling pathway that drives the expression of a common set of genes. However, IFN-lambda signaling is initiated(More)
The interferons λ (IFNsλ), also known as IL-28 and IL-29, are co-expressed with IFNβ following Toll Like Receptor (TLR) stimulation in human monocyte-derived dendritic cells (DCs). IFNλ shares with type I IFNs an intracellular signaling pathway which drives the expression of a common set of gene. However, IFNλ signaling is initiated through a membrane(More)
In humans, type I interferon (IFN) is a family of 17 cytokines, among which the subtypes and the subtype are differentially expressed. It has been suggested that IFNactivates a specific signaling cascade in addition to those activated by all type I IFNs. Nevertheless, no true biological relevance for a differential activity of and IFN subtypes has been(More)
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