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- Frederico Guilherme Graeff, Francisco S Guimarães, Telma Gonçalves Carneiro de Spera Andrade, J F William Deakin
- Pharmacology Biochemistry and Behavior
- 1996
There are conflicting results on the function of 5-HT in anxiety and depression. To reconcile this evidence, Deakin and Graeff have suggested that the ascending 5-HT pathway that originates in the… (More)
- Tatiane Zanelati, Caroline Biojone, Fabricio A Moreira, Francisco S Guimarães, Sâmia Regiane Lourenço Joca
- British journal of pharmacology
- 2010
BACKGROUND AND PURPOSE
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. Effects of CBD may be… (More)
- Alline Cristina de Campos, Francisco S Guimarães
- Psychopharmacology
- 2008
Cannabidiol (CBD) is a non-psychotomimetic constituent of Cannabis sativa plant that induces anxiolytic effects. However, the brain sites and mechanisms of these effects remain poorly understood. The… (More)
- Antônio Waldo Zuardi, R. Reques Cosme, Frederico Guilherme Graeff, Francisco S Guimarães
- Journal of psychopharmacology
- 1993
The effects of ipsapirone and cannabidiol (CBD) on healthy volunteers submitted to a simulated public speaking (SPS) test were compared with those of the anxiolytic benzodiazepine diazepam and… (More)
- Francisco S Guimarães, T. M. Chiaretti, Frederico Guilherme Graeff, Antônio Waldo Zuardi
- Psychopharmacology
- 1990
In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly… (More)
There is conflicting evidence concerning the role of the bed nucleus of the stria terminalis (BNST) in fear and anxiety-elicited behavior. Most of the studies investigating this role, however,… (More)
- Fabricio A Moreira, Daniele Cristina Aguiar, Francisco S Guimarães
- Neuropharmacology
- 2007
Contradictory results exist concerning the effects of systemic injections of CB(1) cannabinoid receptor agonists on anxiety-related behaviors. Direct drug administration into brain structures related… (More)
- Leonardo B. M. Resstel, Sâmia Regiane Lourenço Joca, Fabricio A Moreira, Fernando Morgan de Aguiar Corrêa, Francisco S Guimarães
- Behavioural Brain Research
- 2006
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic-like effects similar to diazepam in animal models of innate aversive behavior. However, the effects of… (More)
Conditioned fear to context causes freezing and cardiovascular changes in rodents and has been used to measure anxiety. It also activates the dorsolateral column of the periaqueductal gray (dlPAG).… (More)
- Sabrina Francesca Lisboa, Leonardo B. M. Resstel, Daniele Cristina Aguiar, Francisco S Guimarães
- European journal of pharmacology
- 2008
There are contradictory results concerning the effects of systemic injections of cannabinoid agonists in anxiety-induced behavioral changes. Direct drug administration into brain structures related… (More)