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Experimental autoimmune encephalomyelitis (EAE) is an inflammatory condition of the central nervous system with similarities to multiple sclerosis. In both diseases, circulating leukocytes penetrate… (More)
- María Mittelbrunn, Cristina Gutiérrez-Vázquez, +5 authors Francisco Sánchez-Madrid
- Nature communications
- 2011
The immune synapse is an exquisitely evolved means of communication between T cells and antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to the transfer of RNA via… (More)
- Olga Barreiro, María Yáñez-Mó, +5 authors Francisco Sánchez-Madrid
- The Journal of cell biology
- 2002
Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by connecting membrane adhesion receptors to the actin-based cytoskeleton. We have studied the interaction of moesin… (More)
- María Yáñez-Mó, Olga Barreiro, Mónica Gordón-Alonso, Mónica Sala-Valdés, Francisco Sánchez-Madrid
- Trends in cell biology
- 2009
Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely in the plane of the membrane. This is because of multiple constraints imposed both by the cortical… (More)
- María Yáñez-Mó, Enrique A Lara-Pezzi, +13 authors Manuel López-Cabrera
- The New England journal of medicine
- 2003
BACKGROUND
During continuous ambulatory peritoneal dialysis, the peritoneum is exposed to bioincompatible dialysis fluids that cause denudation of mesothelial cells and, ultimately, tissue fibrosis… (More)
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
- Carolina Villarroya-Beltri, Cristina Gutiérrez-Vázquez, +7 authors Francisco Sánchez-Madrid
- Nature communications
- 2013
Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other… (More)
How membrane receptors initiate signal transduction upon ligand binding is a matter of intense scrutiny. The T cell receptor complex (TCR-CD3) is composed of TCR alpha/beta ligand binding subunits… (More)
- Hina Kalra, Richard J. Simpson, +53 authors Suresh Mathivanan
- PLoS biology
- 2012
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication,… (More)
- David de Sancho, Manuel Gómez, Francisco Sánchez-Madrid
- Trends in immunology
- 2005
- Francisco Sánchez-Madrid, Alan M. Krensky, +4 authors Timothy A Springer
- Proceedings of the National Academy of Sciences…
- 1982
Monoclonal antibodies were prepared to anti-HLA-DR cytolytic T lymphocytes (CTLs) and screened for inhibition of CTL-mediated killing. Binding of monoclonal antibodies to four types of molecules,… (More)