Francisco Perez Vizcaino

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1. Flavonoids relaxed the contractions induced by noradrenaline, KCl or phorbol 12-myristate, 13-acetate in rat aortic strips, the order of potency being: flavonols (quercetin, kaempferol, pentamethylquercetin) > flavones(luteolin, apigenin) > flavanols((+)-catechin, (-)-epicatechin) which correlates with the reported order of potency to inhibit protein(More)
BACKGROUND Changes in pH can have profound effects on vascular tone and reactivity, but their influence on the ductus arteriosus (DA) remains unknown. OBJECTIVE To analyzethe effects of hypercarbic and normocarbic acidosis in the reactivity of the chicken DA. METHODS DA rings from 19-day chicken fetuses (total incubation time, 21 days) were mounted in a(More)
Recent studies, carried out to prevent thromboembolism in atrial fibrillation, showed a clear benefit of anticoagulant and antiplatelet drugs. Research is now focused to evaluate the antithrombotic effect of: low dose of anticoagulants and the combination of a therapeutic range of antiplatelet drugs and low dose of anticoagulants that may not need(More)
The release of endogenous vasoconstrictors together with changes in the vascular responses are central to the pathophysiology of sepsis. The effects of in vitro incubation for 20 h with heat-killed group B Streptococcus (GBS, 3 x 10(7) colony-forming units mL-1) on the vasoconstrictor responses to noradrenaline (NA, 10(-8) to 10(-4) M), the thromboxane A2(More)
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