Francisco Perez-Balderas

  • Citations Per Year
Learn More
Angiogenesis is an essential component of tumour growth and, consequently, an important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin is a specific marker of angiogenic vessels and the most prevalent vascular integrin that binds the amino acid sequence arginine-glycine-aspartic acid (RGD). Previous studies(More)
OBJECTIVES Optical coherence tomography (OCT) is a high resolution imaging technique used to assess superficial atherosclerotic plaque morphology. Utility of OCT may be enhanced by contrast agents targeting molecular mediators of inflammation. METHODS AND RESULTS Microparticles of iron oxide (MPIO; 1 and 4.5 μm diameter) in suspension were visualized and(More)
Inflammation is a key component of many neurological diseases, yet our understanding of the contribution of these processes to tissue damage remains poor. For many such diseases, magnetic resonance imaging (MRI) has become the method of choice for clinical diagnosis. However, many of the MRI parameters that enable disease detection, such as passive contrast(More)
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast(More)
9 Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, 10 Department of Oncology, University of Oxford, Oxford, OX3 7DQ,UK 11 Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, 12 OX1 3TA,UK. 13 Department of Cardiovascular Medicine and Oxford Acute Vascular Imaging Centre, 14 University(More)
  • 1