Francisco Ledesma

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BACKGROUND Despite effective analgesic therapy, inadequate pain control is frequently perceived by patients and caregivers. AIMS To assess satisfaction with management of pain in cancer patients. METHODS Between January and May 2007, a cross-sectional multicentre study was conducted in 64 Medical Oncology Departments throughout Spain. A total of 525(More)
BACKGROUND AND OBJECTIVES Atypical antipsychotics have been related with hyperglycaemia, diabetes mellitus, weight gain and lipid alterations in some patients. This study analyzed whether continuous treatment with risperidone, olanzapine, or clozapine entails a risk of glucose or lipid metabolism alterations in schizophrenic patients. PATIENTS AND METHOD(More)
INTRODUCTION The purpose of Perfil-es study was to identify the proportion of patients starting ARV treatment based on NNRTIs or PI/r, and to identify the variables involved in the therapeutic decision-making in standard clinical practice. METHODS An observational retrospective study performed in 65 Spanish hospitals. RESULTS Was a total of 1,687(More)
INTRODUCTION To assess the clinical profile and management of patients with hepatitis C (HCV) infection in an observational study in Spanish hospitals. METHODS The study included an initial cross-sectional phase (study phase I), in which investigators at 48 hospitals from 14 Spanish regions collected data from approximately 20 consecutive patients each (a(More)
Resistance to erythromycin is usually associated with resistance to penicillin in Streptococcus pneumoniae isolates. Over the last few years, however, an increase has been detected in the number of Streptococcus pneumoniae isolates obtained from children with acute otitis media complicated by acute mastoiditis. These isolates are characterized by a(More)
INTRODUCTION In 2009 a deep change in ARV treatment took place in Spain with the introduction of new ARV drugs. The principal objective of the study was to determine the clinical situation of the patients in which DRV/r was introduced in the ARV therapy. METHODS Observational, cross sectional and multicentre study in which 91 reference hospitals(More)
The Perfil-es study demonstrated that, while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based initial antiretroviral therapy (ART) is more frequently used in human immunodeficiency virus (HIV)-infected naïve patients, ritonavir-boosted protease inhibitors (PI/r)-based regimens are the preferred option in patients with advanced infectious stages(More)