Francisco J. Rodriguez

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Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A (Lmna), an essential component of the nuclear envelope. Both Zmpste24- and Lmna-deficient mice exhibit profound nuclear architecture abnormalities and multiple histopathological defects that phenocopy an accelerated ageing process. Similarly, diverse human progeroid(More)
Matrix metalloproteinase 19 (MMP-19) is a member of the MMP family of endopeptidases that, in contrast to most MMPs, is widely expressed in human tissues under normal quiescent conditions. MMP-19 has been found to be associated with ovulation and angiogenic processes and is deregulated in diverse pathological conditions such as rheumatoid arthritis and(More)
Biogenesis and recycling of iron-sulfur (Fe-S) clusters play important roles in the iron homeostasis mechanisms involved in mitochondrial function. In Saccharomyces cerevisiae, the Fe-S clusters are assembled into apoproteins by the iron-sulfur cluster machinery (ISC). The aim of the present study was to determine the effects of ISC gene deletion and(More)
Suitability of energy systems based on Superconducting Magnetic Energy Storage (SMES) has been widely tested in the field of wind energy, being able to supply power in cases such as low wind speeds or voltage dips, and to store energy when there are surpluses. This article analyzes and compares the performance of three SMES-based systems that differ in the(More)
The presence of an unbalanced voltage at the point of common coupling (PCC) results in the appearance of a negative sequence current component that deteriorates the control performance. Static synchronous compensators (STATCOMs) are well-known to be a power application capable of carrying out the regulation of the PCC voltage in distribution lines that can(More)
GDF11 has recently emerged as a powerful anti-aging candidate, found in young blood, capable of rejuvenating a number of aged tissues, such as heart, skeletal muscle and brain. However, recent reports have shown contradictory data questioning its capacity to reverse age-related tissue dysfunction. The availability of a mouse model of accelerated aging,(More)