Learn More
BACKGROUND Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. Importantly, results from a large number of biomonitoring studies are at odds with the results from two(More)
BACKGROUND Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels. OBJECTIVES We compared the reasons provided by the European Food Safety Authority (EFSA) BPA risk assessment panel(More)
The standardization of rodent litter sizes (or culling) in reproductive toxicity studies has become a common practice because it is believed that litter size affects pup postnatal growth and development. A claim has also been made that culling on postnatal day 4 or earlier reduces litter-size-induced variability in the pup growth thereby making statistical(More)
In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two different methods of inducing(More)
In developmental toxicity studies, skeleton abnormalities found in fetuses at term are classified as variations or malformations. The relevance of skeleton variations for human risk assessment, however, is a controversial issue. This paper is a contribution to the discussion on the interpretation of fetal skeleton variations in the context of risk(More)
Diether Neubert, toxicologist, and Hans-Joachim Merker, histopathologist and embryologist, made significant contributions to the field of Developmental and Reproductive Toxicology. They worked under the same roof at the Institute of Toxicology and Embryopharmacology in Berlin, and actively collaborated with each other for over 25 years. Both scientists are(More)
  • 1