Francisco J. Moreno

Jesús Avila7
Félix Hernández4
Raúl Reina4
7Jesús Avila
4Félix Hernández
4Raúl Reina
3Ismael Santa-Maria
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Tau aggregation is a common feature of tauopathies such as Alzheimer disease (AD). In AD, tau assembles into fibrillar polymers; it may also be present in other aberrant aggregates, including Hirano bodies. The mechanisms leading to tau polymerization in vivo are not understood. In this study, we found that coenzyme Q (ubiquinone) facilitates tau(More)
Alzheimer's disease (AD) is characterized by the presence of two histopathological hallmarks; the senile plaques, or extracellular deposits mainly composed of amyloid-beta peptide (Abeta), and the neurofibrillary tangles, or intraneuronal inclusions composed of hyperphosphorylated tau protein.Since Abeta aggregates are found in the pathological cases,(More)
Aberrant aggregation of microtubule associated protein tau is the main characteristic of different disorders known as tauopathies. Different compounds have been described to facilitate tau aberrant aggregation. In this work, we demonstrate that oxidized products of dopamine (neurotoxic dopamine quinone), a neurotransmitter involved in Parkinson's disease,(More)
This research studied the effect of different organisations of practice (blocked and random) on the learning of three different types of throwing. 35 male students practiced three precise throws for 3 wk. Initially the subjects were separated into two groups who trained under different conditions of practice (blocked and random). All subjects improved(More)
Experienced athletes in sports with moving objects have shown greater skill when using visual information to anticipate the direction of a moving object than nonexperienced athletes of those sports. Studies have shown that expert athletes are more effective than novices in occlusion situations in the first stages of the sports sequence. In this study, 12(More)
The execution variability and outcomes found in throwing actions have received special attention in numerous studies in recent years. The aim of this study was to analyze the effect of an unstable condition on velocity, accuracy and kinematics of movement in the seven metres throw in handball. Twenty-five young handball players took part in an experiment,(More)
Trunk exercise speed has significant effects on neuro-mechanical demands; however, the influence of a variety of exercise speeds on motor control of the trunk displacement remains unknown. The aim of this study was to assess the effect of performance speed on trunk motion control during the curl-up exercise by analyzing the kinematic variance about the(More)
Studies about the relationship between complexity and performance in upright standing balance have yielded mixed results and interpretations. The aim of the present study was to assess how the increasing difficulty in standing balance task affects performance and the complexity of postural sway and neuromuscular activation. Thirty-two young healthy(More)
Human recombinant tau can bind to the end of isolated human paired helical filaments (PHF). The sequential binding of tau protein to PHF could result in an elongation of the previously polymerized PHF. However, we have observed that the elongation takes place in a different way on different types of PHF. We have found that there are at least three(More)