Francisco Adasme-Carreño

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Manuel Faundez-Parraguez1
Patricio Iturriaga-Vasquez1
Jans Alzate-Morales1
1Manuel Faundez-Parraguez
1Patricio Iturriaga-Vasquez
1Jans Alzate-Morales
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Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to design and synthesise novel α4β2-preferring neonicotinic ligands. We increased the distance between the basic nitrogen and aromatic group(More)
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