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BACKGROUND Surprisingly, the prevalence of polycystic ovary syndrome (PCOS) in otherwise unselected overweight or obese women is unknown, despite obesity being frequent in patients with PCOS. We conducted the present study to obtain an unbiased estimate of the prevalence of PCOS in unselected overweight and obese premenopausal women from Spain. METHODS(More)
BACKGROUND & AIMS Vitamin D deficiency has been recently associated with the metabolic syndrome. However, it is not known whether this possible association of vitamin D deficiency with the metabolic syndrome is still present at very high degrees of obesity, as in morbidly obese patients. METHODS Transversal, observational study that included 73(More)
CONTEXT The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially with regard to its evolution after bariatric surgery. OBJECTIVE The objective of this study was to evaluate the response of PCOS to the sustained and marked weight loss achieved by bariatric surgery(More)
BACKGROUND We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS). METHODS Seventy-six PCOS patients and 40 non-hyperandrogenic women matched for BMI and degree of obesity were included. Serum adiponectin and resistin levels,(More)
CONTEXT Oral contraceptives may worsen the metabolic profile of patients with polycystic ovary syndrome (PCOS), favoring the use of insulin sensitizers in these patients. OBJECTIVE The aim of the study was to compare the effects of a contraceptive pill on metabolic classic cardiovascular risk factors with those of the insulin sensitizer metformin. (More)
BACKGROUND Previous studies addressing the changes in serum visfatin levels after bariatric surgery yielded conflicting results. METHODS We measured serum visfatin levels in 41 morbidly obese women before bariatric surgery and after losing at least 15% of the initial weight, and analyzed the results taking into account the type of surgery, reproductive(More)
W e recently reported (1) that serum ferritin levels are increased in overweight and obese women with polycystic ovary syndrome (PCOS) independently of inflammation. This finding suggested increased body iron stores in these women, raising the possibility that genes related to iron metabolism are altered in PCOS. Classic hereditary hemochromatosis is an(More)
OBJECTIVE Previous studies addressing the influence of thyroid hormones on serum levels of adipokines yielded conflicting results. We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model. DESIGN Twenty-two women with differentiated thyroid carcinoma were studied the last(More)
BACKGROUND We evaluated carotid intima-media thickness (CIMT) as an early marker of atherosclerosis, as well as its main determinants among androgen excess, obesity and insulin resistance, in patients with polycystic ovary syndrome (PCOS). METHODS We selected 40 PCOS patients and 20 non-hyperandrogenic women who were similar in terms of age and grade of(More)
CONTEXT Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis. OBJECTIVE The objective of the investigation was to study the involvement of hepcidin in the iron overload of patients with polycystic ovary syndrome (PCOS). DESIGN This was a case-control study followed by a randomized clinical trial. (More)