Francisca Rojas

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BACKGROUND Tyrosine kinase inhibitors (TKIs) are the recommended treatment for patients with chronic myeloid leukemia (CML). The MDR1/ABCB1 gene plays a role in resistance to a wide spectrum of drugs, including TKIs. However, the association of MDR1/ABCB1 gene polymorphisms (SNPs) such as C1236T, G2677T/A, and C3435T with the clinical therapeutic evolution(More)
This article presents the design of a information system layer to support analytical telemedicine services. We introduce general considerations on the chain of telemedicine value, as well as a query tool that allows flexible and efficient querying of relevant information about performance, scope, effectiveness, and measurements of disease outcomes related(More)
Several commuter rail systems are beginning to accept mobile payments, in which tickets are purchased and validated on smartphones. Mobile payments may improve the rider experience while reducing costs and simplifying the fare collection process for rail operators. Before investing in this new ticketing technology, rail operators want to understand rider(More)
Obese/diabetic mothers present a higher risk to develop offspring with myelomeningocele (MM), evidence supporting the role of energy homeostasis-related genes in neural tube defects. Using polymerase chain reaction-restriction fragment length polymorphism, we have genotyped SLC2A1, HK1, and LEPR single-nucleotide polymorphisms in 105 Chilean patients with(More)
— In today’s world, wireless mobile communications devices are creating new dimensions of interconnectedness between people, places, and urban infrastructure. This ubiquitous connectivity within the environment can be observed and interpreted in real-time through aggregate records collected from communication and transportation networks. The real-time(More)
— In today’s world, wireless mobile communications devices are creating new dimensions of interconnectedness between people, places, and urban infrastructure. This ubiquitous connectivity within the environment can be observed and interpreted in real-time through aggregate records collected from communication and transportation networks. The real-time(More)
Marshall-Smith Syndrome (OMIM 602535) was described initially by Marshall in two infants with a syndrome characterized by accelerated skeletal maturation, failure to thrive, and dysmorphic facial features. We report a new patient with clinical features of Marshall-Smith syndrome with additional findings such as hyperpigmented lines on trunk and the four(More)
Prior studies have assessed the impacts of real-time information (RTI) provided to bus and heavy rail riders but not commuter rail passengers. The objective of this research is to investigate the benefits of providing commuter rail RTI. The method is a three-part statistical analysis using data from an on-board survey on two commuter rail lines in the(More)