Francisca Rojas

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1Marcelo Castro
1Mabel Lardo
1Alberto Lazarowski
1Jorge A Rey
1Natalia Borda
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BACKGROUND Tyrosine kinase inhibitors (TKIs) are the recommended treatment for patients with chronic myeloid leukemia (CML). The MDR1/ABCB1 gene plays a role in resistance to a wide spectrum of drugs, including TKIs. However, the association of MDR1/ABCB1 gene polymorphisms (SNPs) such as C1236T, G2677T/A, and C3435T with the clinical therapeutic evolution(More)
This article presents the design of a information system layer to support analytical telemedicine services. We introduce general considerations on the chain of telemedicine value, as well as a query tool that allows flexible and efficient querying of relevant information about performance, scope, effectiveness, and measurements of disease outcomes related(More)
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