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A highly efficient methodology of asymmetric epoxidation based on a novel chiral sulfur ylide.
A new type of chiral sulfur ylides has been synthesized and their reactivities against carbonyl compounds tested, showing a high degree of stereoselectivity in the formation of trans epoxy amides
A highly stereoselective synthesis of glycidic amides based on a new class of chiral sulfonium salts: applications in asymmetric synthesis.
TLDR
A new type of chiral sulfonium salts that are characterized by a bicyclic system has been designed and synthesized from α-amino acids and were reduced into their corresponding epoxy alcohols and subjected to oxirane-ring-opening reactions with different types of nucleophiles.
Chiral sulfur ylides for the synthesis of bengamide E and analogues.
TLDR
A new synthetic methodology of asymmetric epoxidation developed in the laboratories has been employed for the stereoselective synthesis of bengamide E and analogues at the terminal olefinic position and allowed access to the generation of a wide array of new bENGamide analogues.
Epi-, epoxy-, and C2-modified bengamides: synthesis and biological evaluation.
TLDR
Biological evaluation of all of these bengamide E analogues demonstrated that the polyketide chain is essential for the antitumor activity of these natural products, not being amenable to structural or configurational modifications.
An Array of Bengamide E Analogues Modified at the Terminal Olefinic Position: Synthesis and Antitumor Properties
TLDR
Interestingly, the analogue possessing a cyclopentyl group displayed greater potency than the parent bengamide E, representing a key finding upon which to base further investigations into the design of new analogues with promising biological activities.
Epoxyamide-based strategy for the synthesis of polypropionate-type frameworks.
TLDR
Several aldehydes showed remarkable stereofacial differentiation, providing a major diastereoisomer, in contrast to others that displayed a poor or no stereoselectivity, enhancing the synthetic value of this new methodology for the preparation of typical polypropionate frameworks found in many natural products.