Francis Lopes Pacagnelli

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BACKGROUND Autonomic diabetic neuropathy is one of the most common complications of type 1 diabetes mellitus, and studies using heart rate variability to investigate these individuals have shown inconclusive results regarding autonomic nervous system activation. Aims To investigate the dynamics of heart rate in young subjects with type 1 diabetes mellitus(More)
OBJECTIVE Gather and describe general characteristics of different protocols of risk stratification for cardiac patients undergoing exercise. METHODS We conducted searches in LILACS, IBECS, MEDLINE, Cochrane Library, and SciELO electronic databases, using the following descriptors: Cardiovascular Disease, Rehabilitation Centers, Practice Guideline,(More)
BACKGROUND There are still gaps in the knowledge regarding the damage to mucociliary and autonomous systems from passive exposure to cigarette smoke. Also, the influence of the frequency and duration of exposure on these systems is still unclear. The objective of this work was to verify the effects of passive smoking on mucociliary clearance and adult(More)
The purpose of this study was to examine the effects of free leucine supplementation on changes in skeletal muscle mass and strength during a resistance training (RT) program in previously untrained, young subjects. In a double-blind, randomized, placebo-controlled study, 20 healthy young (22 ± 2 years) participants were assigned to two groups: a(More)
Nitric oxide (NO) has been shown to increase skeletal muscle protein synthesis. However, the role of NO during skeletal muscle regrowth after immobilization remains unknown. The purpose of this study was to determine whether NO is required for muscle regrowth/recovery after a period of disuse by immobilization. Male Wistar rats were divided into 4 groups:(More)
BACKGROUND Right-sided heart failure has high morbidity and mortality, and may be caused by pulmonary arterial hypertension. Fractal dimension is a differentiated and innovative method used in histological evaluations that allows the characterization of irregular and complex structures and the quantification of structural tissue changes. OBJECTIVE To(More)
Pulmonary arterial hypertension (PAH) is a chronic disease which causes overload to the right ventricle. The effect of preventive training on cardiac remodelling in this condition is still unknown. This study aimed to evaluate the influence of preventive training on hypertrophy, heart function and gene expression of calcium transport proteins in rats with(More)
NEW FINDINGS What is the central question of this study? We investigated the effects of physical training on phenotypic (fibre-type content) and myogenic features (MyoD and myogenin expression) in skeletal muscle during the transition from cardiac hypertrophy to heart failure. What is the main finding and its importance? We provide new insight into skeletal(More)
ObjeCtiveS: To compare autonomic modulation in young patients with type 1 diabetes mellitus (DM1) (n=20) and healthy control subjects (n=23) using geometric indexes of heart rate variability (HRV) associated with linear domains of time and frequency; and to verify correlations between geometric indexes and those obtained by the time and the frequency domain(More)
OBJECTIVE To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior. DATA SOURCES The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus",(More)