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The nuclear morphology of WI-38 cells plated on increasing thicknesses of the polymer, poly-2-hydroxyethylmethacrylate, was studied. Changes in nuclear morphometry were found to parallel changes in cellular morphometry: namely a transition to a more rounded and compact conformation, with increasing thicknesses of the polymer. Such changes in nuclear(More)
Opening pressures of the choledochoduodenal junction were measured in anesthetized dogs before and after vagotomy. Measurements were also made in anesthetized, vagotomized dogs prior to and during appropriate electrical stimulation of the severed ends of the peripheral and central vagi and of the peripheral splanchnic nerves. Vagotomy itself was not(More)
Alterations of arterial, hepatic portal, and central venous pressures are shown to be associated with changes in the same direction of the opening pressures of the canine choledochoduodenal junction. Increases in opening pressures subsequent to increases in vascular pressures could be abolished by the intraductal administration of norepinephrine.(More)
Microanatomical evidence is presented which shows that the lumen of the intraduodenal portion of the common bile duct is almost completely filled by folds of a highly vascularized mucosa in the dog, cat, rabbit, and human. These folds are most apparent near the intraduodenal ductal orifice, where they almost completely occlude the lumen. Physiological data(More)
Automated image analyses were performed using Feulgen stained smears of WI-38 cells that were either confluent, or that had received a nutritional stimulus to proliferate 3 hr before collection. These experiments show that it is possible to observe changes in morphometric and densitometric parameters of nuclei that correlate with structural and functional(More)
Directly measured and derived geometric and densitometric parameters were obtained by means of the automated image analyzer Quantimet 720-D in Feulgen-stained HeLa cells synchronized by selective mitotic detachment. These data indicate substantial alteration of nuclear morphology during the entire cell cycle, even during the G1 and G2 phases, and the late(More)