Francis Jingxin Hu

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Antibodies are of importance for the field of proteomics, both as reagents for imaging cells, tissues, and organs and as capturing agents for affinity enrichment in mass-spectrometry-based techniques. It is important to gain basic insights regarding the binding sites (epitopes) of antibodies and potential cross-reactivity to nontarget proteins. Knowledge(More)
  • Pettit, F E Koob, +40 authors R Subunit
  • 2002
30 , and the main bands for GluR1 (5.2 kilobases) and GluR2 (5.9 and 3.9 kilobases) were quantified and normalized relative to b-actin. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus(More)
The unique property of specific high-affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications. Hence knowledge of the precise binding site (epitope) of antibodies on the target protein is one of the most important features for understanding its performance and determining its reliability in(More)
One of the issues in using polyclonal antibodies is the limited amount of reagent available from an immunisation, leading to batch-to-batch variation and difficulties in obtaining the same antibody performance when the same antigen is re-immunised into several separate animals. This led to the development of hybridoma technology allowing, at least(More)
OBJECTIVE To assess the prognosis of rare advanced.cervical carcinoma with post-radical-radiation surgery and to compare the clinic value between further surgery treatment group and non-surgery group after radical radiation therapy. MATERIALS AND METHODS From January 2002 to July 2010 there were 68 patients with advanced stage cervical carcinoma(More)
The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). As recently reported there is a need for a precise classification of eculizumab responsive patients to allow for a safe and cost-effective treatment. To allow for such(More)
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