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Francois Jacob Born 1920 in Nancy, France. Completed M.D. degree (1947) at Faculty of Paris, and a obtained doctorate in Science (1954) at the Sorbonne. Joined Institute Pasteur as research assistant (1950), under Dr. André Lwoff. Appointed Laboratory Director (1956) and Head of Dept. of Cell Genetics (1960). Began collaboration with Monod (1958) at(More)
Reverse Transcription - quantitative Polymerase Chain Reaction (RT-qPCR) is a standard technique in most laboratories. The selection of reference genes is essential for data normalization and the selection of suitable reference genes remains critical. Our aim was to 1) review the literature since implementation of the MIQE guidelines in order to identify(More)
The ETn (for "early transposon") family of long repeated sequences in abundantly transcribed in early mouse embryos from retroviral-like long terminal repeats. Nucleotide sequencing of two elements does not reveal any long open reading frame nor significant homology to retroviral proteins. The genetic polymorphism, monitored by Southern blotting within and(More)
Two cultured lines of murine embryonal carcinoma, F9 and PCC3, have been grafted to a variety of allogeneic hosts. The host strains have been classified by their resistance or sensitivity to these carcinomas. Resistance seems to be immunological in nature. Allograft rejection does not correlate withH-2 haplotype, and seems to be controlled by a limited(More)
Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm copurify with intermediate filaments from trophectoderm and a trophoblastoma cell line. A monoclonal antibody prepared against proteins of these intermediate(More)