Francis H. Ruddle

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It has been suggested that the increase in the number of Hox genes may have been one of the key events in vertebrate evolution. Invertebrates have one Hox cluster, while mammals have four. Interestingly, the number of Hox gene clusters is greater in the teleost fishes, zebrafish and medaka, than in mouse and human. The greater number of Hox clusters in the(More)
The living coelacanth is a lobe-finned fish that represents an early evolutionary departure from the lineage that led to land vertebrates, and is of extreme interest scientifically. It has changed very little in appearance from fossilized coelacanths of the Cretaceous (150 to 65 million years ago), and is often referred to as a "living fossil." An important(More)
Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101 USA,Department of Biology, University of Washington, 106 Kincaid Hall, Seattle, WA 98195 USA,The Stanford Human Genome Center and the Department of Genetics, Stanford University School of Medicine, Palo Alto, CA 94304, USA,Cardiodx, Inc., Palo Alto, 2500 Faber Place, CA(More)
Changes in thymidylate synthetase specific activity in Don Chinese hamster cells grown in vitro have been examined during the culture cycle and after exposure of lagand log-phase cultures to drugs which inhibit DNA, RNA, and protein synthesis. During the culture cycle enzyme activity was low during lag phase, rose 6to 8-fold before log phase, fluctuated(More)
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