Learn More
In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein isoforms - thereby playing a central part in generating complex proteomes. Alternative splicing also has a largely hidden function in quantitative gene control, by targeting RNAs for nonsense-mediated decay. Traditional gene-by-gene(More)
Alternative splicing is widespread in mammalian gene expression, and variant splice patterns are often specific to different stages of development, particular tissues or a disease state. There is a need to systematically collect data on alternatively spliced exons, introns and splice isoforms, and to annotate this data. The Alternative Splicing Database(More)
BACKGROUND The three consensus elements at the 3' end of human introns--the branch point sequence, the polypyrimidine tract, and the 3' splice site AG dinucleotide--are usually closely spaced within the final 40 nucleotides of the intron. However, the branch point sequence and polypyrimidine tract of a few known alternatively spliced exons lie up to 400(More)
Membrane organization describes the orientation of a protein with respect to the membrane and can be determined by the presence, or absence, and organization within the protein sequence of two features: endoplasmic reticulum signal peptides and alpha-helical transmembrane domains. These features allow protein sequences to be classified into one of five(More)
Human transcriptomes are highly diverse, overlapping, complex, and dynamic. Alternative splicing and structural variations play pivotal roles in enhancing the range of transcriptome complexity ([1–7]). The first level complexity is introduced by splicing and alternative splicing of the annotated exons, including Untranslated Regions (UTR's) ([1–3, 7]). The(More)
This multi-year program was based on the premise a digital divide exists between the technology skill levels of public school faculties compared to those of undergraduate teacher education candidates. The Technology Mentor Fellowship Program (TMFP) matched technologically-proficient pre-service teachers with K-12 teachers to model technology as an(More)
  • 1