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- Weijun Li, Francis C. Szoka
- Pharmaceutical Research
- 2006
Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles… (More)
- Rom E Eliaz, Francis C. Szoka
- Cancer research
- 2001
Certain tumors, including many that are found in the lung, overexpress the CD44 cell-surface marker. CD44 is a receptor that binds to hyaluronan (HA), a carbohydrate consisting of beta1,3 N-acetyl… (More)
- Yaoda Xu, Francis C. Szoka
- Biochemistry
- 1996
To understand how DNA is released from cationic liposome/DNA complexes in cells, we investigated which biomolecules mediate release of DNA from a complex with cationic liposomes. Release from… (More)
- M Eugene Fox, Francis C. Szoka, Jean M. J. Fréchet
- Accounts of chemical research
- 2009
Chemotherapy can destroy tumors and arrest cancer progress. Unfortunately, severe side effects (treatment is usually a series of injections of highly toxic drugs) often restrict the frequency and… (More)
- Harma M Ellens, Joe Bentz, Francis C. Szoka
- Biochemistry
- 1985
A new liposome fusion assay has been developed that monitors the mixing of aqueous contents at neutral and low pH. With this assay we have investigated the ability of H+ to induce membrane… (More)
- Francis C. Szoka, F R Olson, Trevor J. Heath, W. J. Vail, Eric Mayhew, Demetrios Papahadjopoulos
- Biochimica et biophysica acta
- 1980
Liposomes can be prepared by a combination of reverse phase evaporation and sequential extrusion through polycarbonate membranes. The vesicles have diameters in the range 0.05-0.5 micron and are… (More)
- Richard N. Cohen, Marieke A E M van der Aa, Nichole F Macaraeg, Ai Ping Lee, Francis C. Szoka
- Journal of controlled release : official journal…
- 2009
Nuclear uptake of plasmid DNA is one of the many cellular barriers that limit the efficiency of non-viral gene delivery systems. We have determined the number of plasmids that reach the nucleus of a… (More)
- Elizabeth R Gillies, Edward E Dy, Jean M. J. Fréchet, Francis C. Szoka
- Molecular pharmaceutics
- 2005
High molecular weight (MW) polymers have shown promise in terms of improving the properties and the efficacy of low MW therapeutics. However, new systems that are highly biocompatible, are… (More)
- F R Olson, C. Anthony Hunt, Francis C. Szoka, W. J. Vail, Demetrios Papahadjopoulos
- Biochimica et biophysica acta
- 1979
Liposomes of defined size and homogeneity have been prepared by sequential extrusion of the usual multilamellar vesicles through polycarbonate membranes. The process is easy, reproducible, produces… (More)
- Johannes H Hänsler, Francis C. Szoka
- Bioconjugate chemistry
- 1993
Cascade polymers also known as Starburst dendrimers are spheroidal polycations that can be synthesized with a well-defined diameter and a precise number of terminal amines per dendrimer. We show,… (More)