Francis B. Grinnell

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The principles upon which prophylactic inoculation against typhoid fever is based are unquestionably sound, and there can be no doubt of the fact that the procedure has considerably diminished the incidence of the disease during the last thirty years. The instances of the failure of antityphoid vaccine to protect against infection are, however, not so rare(More)
A study of the subcultures of the Rawlins strain of Bacterium typhosum used by twelve different laboratories for vaccine production showed that they all differed from recently isolated smooth strains in cultural characteristics, virulence and protective efficiency. Eleven of these Rawlins cultures gave both the flagellar and the somatic type of(More)
Serological analyses of the constitution of the motile bacilli have established the existence of a heat-labile agglutinogen associated with the flagellae and of a heat-stable agglutinogen contained in the bacil-lary bodies. Whereas there appears to be no antigenic difference in the flagellar substance of the smooth and the rough forms, the studies of the(More)
The results of cross-agglutination and agglutinin absorption experiments with the motile smooth, non-motile smooth, motile rough, and non-motile rough forms of B. typhosus are presented. Cross-agglutination between these four forms is complete, save that the motile rough antigen is under certain conditions only weakly agglutinated by the antisera prepared(More)
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