Francesca Simonelli15
Settimio Rossi10
Michele Della Corte4
15Francesca Simonelli
10Settimio Rossi
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The safety and efficacy of gene therapy for inherited retinal diseases is being tested in humans affected with Leber's congenital amaurosis (LCA), an autosomal recessive blinding disease. Three independent studies have provided evidence that the subretinal administration of adeno-associated viral (AAV) vectors encoding RPE65 in patients affected with LCA2(More)
AIM The aim of the study was to describe the clinical and genetic features of 15 Italian patients with Bietti crystalline dystrophy (BCD). METHODS All study participants underwent a complete ophthalmological examination, including standard electroretinogram (ERG), optical coherence tomography, microperimetry, autofluorescence and multifocal(More)
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their(More)
  • Diego Vozzi, Anu Aaspõllu, Emmanouil Athanasakis, Anna Berto, Antonella Fabretto, Danilo Licastro +9 others
  • 2011
PURPOSE Usher syndrome is an autosomal recessive disorder characterized by hearing and vision loss. Usher syndrome is divided into three clinical subclasses (type 1, type 2, and type 3), which differ in terms of the severity and progression of hearing loss and the presence or absence of vestibular symptoms. Usher syndrome is defined by significant genetic(More)
BACKGROUND Inherited retinal dystrophies, including Retinitis Pigmentosa and Leber Congenital Amaurosis among others, are a group of genetically heterogeneous disorders that lead to variable degrees of visual deficits. They can be caused by mutations in over 100 genes and there is evidence for the presence of as yet unidentified genes in a significant(More)
AIM To investigate the prevalence of macular abnormalities in a large Caucasian cohort of patients affected by retinitis pigmentosa (RP). METHODS A retrospective study was performed by reviewing the medical records and optical coherence tomography (OCT) scans in a cohort of 581 RP patients in order to assess the presence of macular abnormalities -that is,(More)
Keywords: EMAS ISO 14001 Environmental performance CO 2 emissions a b s t r a c t Despite the importance that environmental management systems have in the environmental policy agenda, the debate on their effectiveness to improve environmental performance (e.g. the reduction of polluting emissions) is still open among researchers and practitioners.(More)
Our paper analyses the link between the adoption of corporate social responsibility (CSR) and competitiveness performance among small and medium enterprises operating in the fashion industry. The study refers to a sample of 213 SMEs (Small and Medium sized Enterprises) located in Italy and France and is based on a correlation analysis between(More)
BACKGROUND Objective techniques to assess the amelioration of vision in patients with impaired visual function are needed to standardize efficacy assessment in gene therapy trials for ocular diseases. Pupillometry has been investigated in several diseases in order to provide objective information about the visual reflex pathway and has been adopted to(More)
PURPOSE To report on 4 patients affected by Stargardt's disease (STGD) with fundus flavimaculatus (FFM) and ABCA4 gene mutation associated with subretinal fibrosis. METHODS Four patients with a diagnosis of STGD were clinically examined. All 4 cases underwent a full ophthalmologic evaluation, including best-corrected visual acuity measured by the Snellen(More)