Francesco S Amodeo

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BACKGROUND The current study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would increase the duration of antinociception to a thermal stimulus in a dose-dependent fashion in a rat model of sciatic nerve blockade. METHODS Fifty adult Sprague-Dawley rats (10 rats/group) received unilateral sciatic nerve blocks with 0.2 ml(More)
BACKGROUND The current study was designed to test the hypothesis that the increased duration of analgesia caused by adding dexmedetomidine to local anesthetic results from blockade of the hyperpolarization-activated cation (I(h)) current. METHODS In this randomized, blinded, controlled study, the analgesic effects of peripheral nerve blocks using 0.5%(More)
BACKGROUND AND OBJECTIVES The present study was designed to test the hypothesis that perineural dexmedetomidine provides a longer duration of analgesia than the same dose given subcutaneously in a peripheral nerve block in rats. METHODS Fifty-four rats received unilateral sciatic nerve blocks along with a subcutaneous injection at the base of the neck by(More)
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