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A comprehensive study of haemostasis has been performed in a homogeneous group of 20 patients with nephrotic syndrome without renal failure. We have found unchanged number of platelets and a significant increase of platelet adhesiveness and aggregation; increased levels of activity and related antigen of fibrinogen, of factor VIII, of activity of factors(More)
Hepatitis C viruses (HCV) present in 110 Italian patients were characterized by genotype-specific PCRs. Among the 65 cases of community-acquired hepatitis, HCV genotype II was dominant (60%), followed by genotypes IV (15%), III (11%), and I (3%). Among the 45 hemophilia-associated cases, the distribution of the four HCV genotypes was markedly different:(More)
Patients infected with hepatitis C virus (HCV) were examined with four commercial HCV immunoblotting assays and for anti-GOR antibody to ascertain whether serological findings varied with the genotype of the infecting virus. The results indicate that patients infected with different HCV genotypes tend to show different immunoblotting profiles, mainly due to(More)
BACKGROUND Polytransfused patients may be dually infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV). OBJECTIVES To assess the correlation of antibodies to HCV with viral RNA in serum as determined by polymerase chain reaction (PCR) in anti HIV-positive and -negative haemophiliacs. STUDY DESIGN Serum from 150 Patients with or(More)
Prophylaxis replacement therapy has been assessed for a period of 12 months in 10 patients with severe haemophilia B showing a high incidence of spontaneous bleeding episodes. Two different schedules of administration of a freeze-dried factor IX concentrate were randomly evaluated: according to scheme A, 7.5 U/kg were administrated biweekly, whereas scheme(More)
Advances in technology of semiconductor make nowadays possible to design Chip Multiprocessor Systems equipped with huge on-chip Last Level Caches. Due to the wire delay problem, the use of traditional cache memories with a uniform access time would result in unacceptable response latencies. NUCA (Non Uniform Cache Access) architecture has been proposed as a(More)
Improvements in semiconductor nanotechnology have continuously provided a crescent number of faster and smaller per-chip transistors. Consequent classical techniques for boosting performance, such as the increase of clock frequency and the amount of work performed at each clock cycle, can no longer deliver to significant improvement due to energy constrains(More)
Modern systems are able to put two or more processors on the same die (Chip Multiprocessors, CMP), each with its private caches, while the last level caches can be either private or shared. As these systems are affected by the wire delay problem, NUCA caches have been proposed to hide the effects of such delay in order to increase performance. A CMP system(More)
Antithrombin III (At-III) activity and protein, heparin cofactor activity, antifactor Xa activity were determined in 200 healthy adults, evenly distributed within age and sex groups, in 60 patients with cerebral thrombosis and in 20 oral contraceptive users. There was a positive correlation between At-III protein and its activities in normal subjects and in(More)
Non Uniform Cache Architectures (NUCA) are a novel design paradigm for large last-level on-chip caches which have been introduced to deliver low access latencies in wire-delay dominated environments. Typically, NUCA caches make use of a network-on-chip (NoC) to connect the different sub-banks and the cache controller. This work analyzes how different(More)