In this work a new clustering approach is used to explore a well- known dataset [Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., et al. (2002). Molecular biology of the cell: Vol. 13. Identification of genes periodically expressed in the human cell cycle and their expression in tumors (pp. 1977-2000)] of time… (More)
In this work a comprehensive multi-step machine learning data mining and data visualization framework is introduced. The different steps of the approach are: preprocessing, clustering, and visualization. A preprocessing based on a Robust Principal Component Analysis Neural Network for feature extraction of unevenly sampled data is used. Then a… (More)
This article is not intended as a comprehensive survey of data mining applications in cancer. Rather, it provides starting points for further, more targeted, literature searches, by embarking on a guided tour of computational intelligence applications in cancer medicine, structured in increasing order of the physical scales of biological processes.
An incremental, loosely planned development approach is often used in bioinformatic studies when dealing with custom data analysis in a rapidly changing environment. Unfortunately, the lack of a rigorous software structuring can undermine the maintainability, communicability and replicability of the process. To ameliorate this problem we propose the Leaf… (More)
In this work a multi-step approach for clustering assessment, visualization and data validation is introduced. Three main approaches for data clustering are used and compared: K-means, self organizing maps and probabilistic principal surfaces. A model explorer approach with different similarity measures is used to obtain the best parameters of the methods.… (More)
: Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels. However, the noisy nature of the gene expression and the scarcity of genomic data for many diseases are important limitations to such approaches. Here… (More)
SUMMARY Elucidation of molecular targets of a compound [mode of action (MoA)] and its off-targets is a crucial step in drug development. We developed an online collaborative resource (MANTRA 2.0) that supports this process by exploiting similarities between drug-induced transcriptional profiles. Drugs are organized in a network of nodes (drugs) and edges… (More)