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Our aim was to perform a comprehensive analysis of the global and segmental features of gait in patients with genetically confirmed inherited ataxias. Sixteen patients with autosomal dominant (spinocerebellar ataxia, SCA1 or 2) or recessive (Friedreich’s ataxia, FRDA) ataxia were studied. We used a motion analysis system to record gait kinematic and kinetic(More)
A compact description of coordinated muscle activity is provided by the factorization of electromyographic (EMG) signals. With the use of this approach, it has consistently been shown that multimuscle activity during human locomotion can be accounted for by four to five modules, each one comprised of a basic pattern timed at a different phase of gait cycle(More)
Increased antagonist muscle co-activation, seen in motor-impaired individuals, is an attempt by the neuromuscular system to provide mechanical stability by stiffening joints. The aim of this study was to investigate the co-activation pattern of the antagonist muscles of the ankle and knee joints during walking in patients with cerebellar ataxia, a(More)
We present T` ıpalo, an algorithm and tool for automatically typing DBpedia entities. T` ıpalo identifies the most appropriate types for an entity by interpreting its natural language definition, which is extracted from its corresponding Wikipedia page abstract. Types are identified by means of a set of heuristics based on graph patterns, dis-ambiguated to(More)
FRED is a machine reading tool for converting text into internally well-connected and quality linked-data-ready ontologies in web-service-acceptable time. It implements a novel approach for ontology design from natural language sentences, combining Discourse Representation Theory (DRT), linguistic frame semantics, and Ontology Design Patterns (ODP). The(More)
The vestibulo-ocular reflexes (VORs) were studied in guinea pigs receiving daily administration of aminoglycoside antibiotics. The vestibular epithelia were also examined by scanning electron microscope technique (SEM). The treatment with aminoglycosides led to varying degrees of VORs according to (i) the type of aminoglycoside drug; (ii) the duration of(More)
Twenty four workers (10 involved in the preparation and 14 in administration) exposed to cyclophosphamide (CP) and ifosfamide (IF) in two Italian hospitals were monitored. The extent of exposure was assessed by the analysis of air samples, wipe samples, pads and gloves. Urinary excretion at the beginning and at the end of the work shift was also measured by(More)
We have implemented a novel approach for robust ontology design from natural language texts by combining Discourse Representation Theory (DRT), linguistic frame semantics, and ontology design patterns. We show that DRT-based frame detection is feasible by conducting a comparative evaluation of our approach and existing tools. Furthermore, we define a(More)
People with Parkinson's disease (PD) often have a posture characterized by lateral trunk flexion poorly responsive to antiparkinsonian drugs. To examine the effects of a rehabilitation programme (daily individual 90-minute-sessions, 5-days-a-week for 4-consecutive weeks) on lateral trunk flexion and mobility, 22 PD patients with mild to severe lateral trunk(More)
This study aims to evaluate trunk local stability in a group of patients with degenerative primary cerebellar ataxia and to correlate it with spatio-temporal parameters, clinical variables, and history of falls. Sixteen patients affected by degenerative cerebellar ataxia and 16 gender- and age-matched healthy adults were studied by means of an inertial(More)